NDLI: Molecular characterization of H3N2 and H4N6 subtypes avian influenza viruses isolated from mallards in Poyang Lake, China in 2010

Content Provider	Springer Nature Link
Author	Zhu, Na Zhao, JiuRu Li, YongDong Ding, ChangQing Xia, Han Tang, Shuang Zhang, Zhong Yu, JingFeng Chen, Jing Fan, ZhaoJun Kou, Zheng Li, TianXian
Copyright Year	2012
Abstract	Poyang Lake is the largest inland freshwater lake in China and contains many species of wild birds and waterfowls. We conducted a survey of avian influenza viruses in nine semi-artificial waterfowl farms in Poyang Lake during January to March of 2010. Out of 1036 cloacal swabs collected, three H3N2 and one H4N6 influenza viruses were isolated from healthy mallards. All the isolates were genetically and phylogenetically characterized. The analysis of putative HA cleavage sites showed that all the four isolates possessed the molecular characteristics (QTRGL for H3N2 viruses, PEKASR for H4N6 virus) of lowly pathogenic avian influenza (LPAI) virus. The phylogenetic analysis of the viral genomes showed that all four virus isolates clustered in the Eurasian clade of influenza viruses. The M gene of the viruses possessed the highest homology with highly pathogenic H5N1 influenza viruses. In addition, co-infection of H3N2 and H4N6 in the same farm was observed. And interestingly, we isolated two subtypes viruses (H3N2 and H4N6) and their progeny virus (H3N2) with evidence of genome reassortment from the same farm, in which the PB1 and PB2 gene segments of H4N6 replaced those of the H3N2 strain. The results of animal infection experiments showed that all the four isolated viruses were lowly pathogenic to chickens and not pathogenic to mice, which was consistent with the results of genetic analysis.
Starting Page	3586
Ending Page	3594
Page Count	9
File Format	PDF
ISSN	10016538
Journal	Chinese Science Bulletin
Volume Number	57
Issue Number	27
e-ISSN	18619541
Language	English
Publisher	SP Science China Press
Publisher Date	2012-07-10
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	influenza A virus Poyang Lake epidemic survey evolution Science Chemistry/Food Science Earth Sciences Engineering Life Sciences Physics
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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