NDLI: Development and application of tumor-targeting magnetic nanoparticles FA-StNP@Fe$_{2}$O$

Content Provider	Springer Nature Link
Author	Zheng, YuanQing Tong, ChunYi Wang, Bei Xie, Ying Liao, HongDong Li, Dan Liu, XuanMing
Copyright Year	2009
Abstract	Modified magnetic starch nanoparticles (FA-StNP@Fe$_{2}$O$_{3}$) were synthesized by conjugating folic acid (FA-PEG-NH$_{2}$) onto the surface of magnetic starch nanoparticles (StNP@Fe$_{2}$O$_{3}$) prepared by reverse microemulsion method. The synthesized FA-StNP@Fe$_{2}$O$_{3}$ was investigated by transmission electron microscopy and zeta potential analysis. The average size of its well dispersed particles was 250 nm. The iron concentration of 2 mg/g was detected by phenanthroline method. Placing FA-StNP@Fe$_{2}$O$_{3}$ nanoparticles in the alternating magnetic field for 30 min resulted in an increase in the suspension temperature from ambient temperature (37°C) to a value between 42°C and 43°C. Co-cultured nanoparticles and Hela cell line or normal HUEC-12 cell line, and the biological effects at the cellular level were investigated in the alternating magnetic field using MTT assay, Hochest-PI double staining and flow cytometry analysis. Experimental results showed that FA-StNP@Fe$_{2}$O$_{3}$ within acertain concentration range has no obvious effect on cell proliferation. When treated in the magnetic field, apoptosis rate on Hela induced by FA-StNP@Fe$_{2}$O$_{3}$ was 13.4%. Prussian blue staining analysis confirmed that the nanoparticles modified with folic acid had improved ability in tumor cell-targeting, and therefore, potential applications in biomedical and magnetocaloric areas. It is expected be applied in tumor targeting therapy in the near future.
Starting Page	2998
Ending Page	3004
Page Count	7
File Format	PDF
ISSN	10016538
Journal	Chinese Science Bulletin
Volume Number	54
Issue Number	17
e-ISSN	18619541
Language	English
Publisher	SP Science in China Press
Publisher Date	2009-08-30
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	magnetic nanoparticles folic acid tumor cell-targeting magnetic hyperthermia apoptosis Engineering Earth Sciences Chemistry/Food Science Physics Life Sciences Science
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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