NDLI: Spike protein homology between the SARS-associated virus and murine hepatitis virus implies existence of a putative receptor-binding region

Content Provider	Springer Nature Link
Author	Lu, Yun Chen, Yinghua
Copyright Year	2003
Abstract	Coronavirus has been determined to be the cause of the recent outbreak of severe acute respiratory syndrome (SARS). Human coronavirus 229E had been studied well and its receptor-binding domain was restricted to aa417–547 of S protein. However, this region has no homology with the newly separated SARS-associated virus (Hong Kong isolate CUHK-W1). Then we analyzed the phylogenesis of S1 subunit of the coronavirus spike protein (SARS-associated virus, Hong Kong isolate CUHK-W1). Interestingly, the highest homology between murine hepatitis virus (MHV) and SARS-associated coronavirus was found. And the important sites (aa62–65 and aa214–216) on the spike protein of MHV with receptor-binding capacity were highly conservative in comparison with the newly separated SARS-associated virus (the corresponding sites are aa51–54 and aal95–197). These results from bioinformatics analysis might help us to study the receptor-binding sites of SARS-associated virus and the mechanism of the virus entry into the target cell, and design antiviral drugs and potent vaccines.
Starting Page	1115
Ending Page	1117
Page Count	3
File Format	PDF
ISSN	10016538
Journal	Chinese Science Bulletin
Volume Number	48
Issue Number	11
e-ISSN	18619541
Language	English
Publisher	Science in China Press
Publisher Date	2003-01-01
Publisher Place	Beijing
Access Restriction	Subscribed
Subject Keyword	SARS-associated virus receptor-binding sites humancoronavirus murine hepatitis virus Science Life Sciences Physics Chemistry/Food Science Earth Sciences Engineering
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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