NDLI: Synergistic effect of trace elements and flavonoids from Epimedium koreanum Nakai on primary osteoblasts

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Synergistic effect of trace elements and flavonoids from Epimedium koreanum Nakai on primary osteoblasts

Content Provider	Springer Nature Link
Author	Zhang, DaWei Cheng, Yan Zhang, JinChao Wang, XinLuan Wang, NaiLi Chen, Yao Yang, MengSu Yao, XinSheng
Copyright Year	2008
Abstract	Several trace elements, particularly, manganese (Mn) and zinc (Zn), are essential in bone metabolism as cofactors for specific enzymes. It has been reported that there exists the relationship between osteoporosis and trace element-deficiency and the efficacy of Ca, Mn and Zn supplementation on spinal bone mineral density in postmenopausal women. Traditional Chinese medicines (TCM), such as Herba epimedii, were proved to be effective for prevention of osteoprosis in vivo; however, the efficacy of the main constituents and/or crude extract was not ideal in vitro, which suggested that they may work in another way. The purpose of the present study was to examine whether the combination of icariin and total flavonoids (TF) from Herba epimedii with mineral elements, which were abundant in Herba epimedii, would have a more beneficial effect on the viability and differentiation of primary osteoblasts than either agent alone, and to analyze the dada for a possible synergistic, additive or antagonistic effect. The combinations of 10 μmol/L Zn, Ca and Mn with icariin and total flavonoids greatly improved the cell viability and meanwhile dramatically enhanced the alkaline phosphatase activity as compared to each agent alone. On the other hand, an increased cell growth inhibition was also observed by combining 0.1 μmol/L, 1 μmol/L Zn with 10 μmol/L icariin, and 10 μmol/L Mn with 0.06 μg/mL total flavonoids. Meanwhile a decreased alkaline phosphatase activity was also found in several icariin-Zn/Mn and total flavonoids-Zn/Ca/Mn combinations. These results suggested that mineral elements (Zn, Ca, Mn) greatly enhanced the efficacy of icariin and total flavonoids from Herba epimedii on the viability and differentiation of primary osteoblasts by certain combinations.
Starting Page	347
Ending Page	356
Page Count	10
File Format	PDF
ISSN	10016538
Journal	Chinese Science Bulletin
Volume Number	53
Issue Number	3
e-ISSN	18619541
Language	English
Publisher	Science in China Press
Publisher Date	2008-01-01
Publisher Place	Beijing
Access Restriction	Subscribed
Subject Keyword	Herba epimedii icariin total flavonoids calcium zinc manganese osteoblast viability differentiation synergism Life Sciences Physics Chemistry/Food Science Science Geosciences Engineering
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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