NDLI: Targeting strategies for adeno-associated viral vector

Content Provider	Springer Nature Link
Author	Wang, YiGang Huang, Fang Cai, Rong Qian, Cheng Liu, XinYuan
Copyright Year	2007
Abstract	Adeno-associated virus (AAV) has rapidly become a promising gene delivery vector for its excellent advantages of low pathogenicity and long-term gene expression over other viral vectors for human gene therapy. However, the disadvantage of AAV for clinical gene therapy is the broad host range and the lack of tissue or cell specificity, which makes AAVs relatively inefficient gene delivery to target cells and short of safety. Therefore, it is required to improve the targeting capability of recombinant adeno-associated virus (rAAV) for successful gene therapy. At present, the successful identification of various-serotype AAVs and the improvement of rAAV production technology make it feasible to explore new applications of rAAV vector in clinical gene therapy trials. Moreover, the current development in targeting strategy has brought a bright prospect to rAAV vectors. Many studies have demonstrated that targeting gene therapy based on rAAV vectors could be achieved through transcription targeted, conjugate targeted, receptor targeted, gene recombinant targeted strategies, etc. This report gives a comprehensive review of the recent developments of targeting strategies for rAAV vectors.
Starting Page	1590
Ending Page	1599
Page Count	10
File Format	PDF
ISSN	10016538
Journal	Chinese Science Bulletin
Volume Number	52
Issue Number	12
e-ISSN	18619541
Language	English
Publisher	Science in China Press
Publisher Date	2007-01-01
Publisher Place	Beijing
Access Restriction	Subscribed
Subject Keyword	AAV targeting gene therapy Science Physics Chemistry/Food Science Life Sciences Geosciences Engineering
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
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