NDLI: Pre-irradiation with low-dose $^{12}$C$^{6+}$ beam significantly enhances the efficacy of AdCMV-p53 gene therapy in human non-small lung cancer

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Science in China Series G : Volume 50, Issue 1, February 2007

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Science in China Series G : Volume 46

Pre-irradiation with low-dose $^{12}$C$^{6+}$ beam significantly enhances the efficacy of AdCMV-p53 gene therapy in human non-small lung cancer

Content Provider	Springer Nature Link
Author	Liu, Bing Zhang, Hong Li, WenJian Li, Qiang Zhou, GuangMing Xie, Yi Hao, JiFang Min, FengLing Zhou, QingMing Duan, Xin
Copyright Year	2007
Abstract	The combination of ionizing radiation and gene therapy has been investigated. However, there are very few reports about the combination of heavy-ion irradiation and gene therapy. To determine if the pre-exposure to low-dose heavy ion beam enhances the suppression of AdCMV-p53 on non-small lung cancer (NSLC), the cells pre-irradiated or non-irradiated were infected with 20, 40 MOI of AdCMV-p53. Survival fraction and the relative biology effect (RBE) were determined by clonogenic assay. The results showed that the proportions of p53 positive cells in $^{12}$C$^{6+}$ beam induced AdCMV-p53 infected cells were more than 90%, which were significantly more than those in γ-ray induced AdCMV-p53 infected cells. The pre-exposure to low-dose $^{12}$C$^{6+}$ beam significantly prevented the G$_{0}$/G$_{1}$ arrest and activated G$_{2}$/M checkpoints. The pre-exposure to $^{12}$C$^{6+}$ beam significantly improved cell to apoptosis. RBEs for the $^{12}$C$^{6+}$ + AdCMV-p53 infection groups were 30%–60%, 20%–130% and 30%–70% more than those for the $^{12}$C$^{6+}$-irradiated only, AdCMV-p53 infected only, and γ-irradiation induced AdCMVp53 infected groups, respectively. The data suggested that the pre-exposure to low-dose $^{12}$C$^{6+}$ beam significantly promotes exogenous p53 expression in NSLC, and the suppression of AdCMV-p53 gene therapy on NSLC.
Starting Page	221
Ending Page	230
Page Count	10
File Format	PDF
ISSN	16721799
Journal	Science in China Series G
Volume Number	50
Issue Number	2
e-ISSN	18622844
Language	English
Publisher	Science in China Press
Publisher Date	2007-01-01
Publisher Place	Beijing
Access Restriction	Subscribed
Subject Keyword	heavy-ion beam gene therapy p53 non-small lung cancer adenoviral vector low dose Physics Mechanics, Fluids, Thermodynamics Astronomy
Content Type	Text
Resource Type	Article
Subject	Physics and Astronomy

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