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| Content Provider | Springer Nature Link |
|---|---|
| Author | Chen, Mei Xu, Jin |
| Copyright Year | 2015 |
| Abstract | Currently, there are a lot of man-made biomolecular computing systems. However, it is rare to see man-made biomolecular intelligence system. Learning ability is one of the basic abilities of intelligence. Many organisms have learning ability naturally. In this paper, we have successfully designed, constructed, and tested a genetic conditional learning system in the bacterium Escherichia coli. The system can recognize ‘bad guy’ signal with the help of ‘study’ signal. The function was realized by combining biomolecular AND gate and memory inverter. The AND gate used riboswitch as computation tool, and the memory inverter used Cre recombinase. Flow cytometry was used to verify the function of the system. This study is an attempt of constructing manmade biomolecular intelligence system. The system may lead to new applications for biomolecular computing, artificial intelligence, and biotherapy.本文通过联用与门和记忆反相器两种生物分子计算部件, 在大肠杆菌内构建了一个条件学习系统。该系统能在“学习”信号的帮助下认识“坏人”。初始状态下, 该系统会欢迎“坏人”( 发出黄色荧光) ; 当“学习”信号和“坏人”同时出现时, 系统产生记忆; 之后, 系统不再欢迎“坏人”。本项研究是人工构建生物分子智能系统的一次有益尝试。 |
| Starting Page | 1 |
| Ending Page | 6 |
| Page Count | 6 |
| File Format | |
| ISSN | 1674733X |
| Journal | Science in China Series : Information Sciences |
| Volume Number | 58 |
| Issue Number | 11 |
| e-ISSN | 18691919 |
| Language | Chinese |
| Publisher | Science China Press |
| Publisher Date | 2015-09-16 |
| Publisher Place | Beijing |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | biomolecular computing artificial intelligence conditional learning memory riboswitch DNA recombinase Information Systems and Communication Service |
| Content Type | Text |
| Resource Type | Article |
| Subject | Computer Science |
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