NDLI: The protection effect of β-CD on DNA damage induced by ultrafine TiO$

Content Provider	Springer Nature Link
Author	Zhu, RongRong Wang, ShiLong Sun, XiaoYu Zhang, Rui Yao, SiDe
Copyright Year	2007
Abstract	Under the photocatalysis of 365 nm ultraviolet radiation, ultrafine TiO$_{2}$ caused the oxidative damage of Teasy plasmid DNA. The damage was determined by gel-electrophoresis. Then, a different dose of β-CD was added to the reaction, and the damage was restrained. The rate of damage restraining reached 97% when the mass of β-CD was 4 times as that of TiO$_{2}$. Through UV scan and IR spectroscopy, it was found that the Ti—O of ultrafine TiO$_{2}$ was bound with —OH of β-CD cavum and the —OH on the surface of ultrafine TiO$_{2}$ disappeared, so the formation of ·OH was controlled. The ultrafine TiO$_{2}$ has been widely used, but it was determined to be carcinogenic by some research. The protection effect of β-CD to DNA in the molecular level takes a new look on the surface modification of nano particles to decrease the toxic effect.
Starting Page	272
Ending Page	275
Page Count	4
File Format	PDF
ISSN	10069291
Journal	Science in China Series B: Chemistry
Volume Number	50
Issue Number	2
e-ISSN	18622771
Language	English
Publisher	Science in China Press
Publisher Date	2007-01-01
Publisher Place	Beijing
Access Restriction	Subscribed
Subject Keyword	β-CD ultrafine TiO$_{2}$ plasmid DNA oxide damage bond reaction damage restrain Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Chemistry

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