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| Content Provider | Springer Nature Link |
|---|---|
| Author | Li, ShuiHong Wu, ChangYu Lv, XiaYi Tang, Xiao Zhao, XinQing Yan, Hong Jiang, Hui Wang, XueMei |
| Copyright Year | 2012 |
| Abstract | Antimicrobial resistance has now become a very serious global public health problem. New drug discovery and development are urgently needed to combat the growing threat of multidrug-resistant (MDR) bacteria. The aim of this study was to explore the potential application of three ferrocene-carborane derivatives as new promising agents to confront the problem of increasing antibiotic resistance. The results of agar diffusion bioassay, minimal inhibitory concentrations (MIC) testing and time-kill assay illustrate their broad-spectrum antimicrobial activities to both American Type Culture Collection (ATCC) control strains and MDR clinical isolates. It is evident that the relevant antimicrobial properties are all in a dose-dependent manner and gradually transform into a bactericidal effect from a bacteriostatic effect with the increasing of the drug concentration. Furthermore, these ferrocene-carborane derivatives have no/little toxic effect on normal cells like HELF cells and lead to little hemolysis at their MICs. This raises the possibility to develop novel antimicrobial drugs using these new ferrocene carborane derivants. |
| Starting Page | 2388 |
| Ending Page | 2395 |
| Page Count | 8 |
| File Format | |
| ISSN | 16747291 |
| Journal | Science in China Series B: Chemistry |
| Volume Number | 55 |
| Issue Number | 11 |
| e-ISSN | 18691870 |
| Language | English |
| Publisher | SP Science China Press |
| Publisher Date | 2012-05-29 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | multidrug-resistant bacteria ferrocene-carborane derivatives bactericidal effect biocompatibility minimal inhibitory concentration Chemistry/Food Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
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