NDLI: Size-dependent hydroxyl radicals generation induced by SiO$_{2}$ ultra-fine particles: The role of surface iron

Content Provider	Springer Nature Link
Author	Shang, Yu Zhu, Tong Li, Yi Zhao, JinCai
Copyright Year	2009
Abstract	Oxidative stress and hydroxyl radicals (·OH) play important roles in adverse health effects caused by inhalable ambient air particles (PM$_{10}$). The ultra-fine fraction of PM$_{10}$ has been hypothesized as one of the critical contributors to ·OH generation. Both in vivo and in vitro studies have shown that ultra-fine particles (UFPs) or nano-particles generate more ·OH than larger particles with identical mass and composition. Both the surface area and surface-adsorbed redox-active metals have been suggested as factors to determine the oxidative capacity of UFPs. In this study, the ·OH-generating capability of different sizes of SiO$_{2}$ particles was investigated in order to determine which factor influences particle-induced ·OH generation. The amount of ·OH generated in both acellular and cellular systems was quantified using a capillary electrophoresis method following exposure to SiO$_{2}$ particles with diameters of 14, 100, and 500 nm. The amount of ·OH was strongly dependent on particle size, and a significant enhancement was observed only with 14 nm particles. Further studies indicated a close association between ·OH and iron ion concentration (R $^{2}$ = 0.812, p<0.01). Washed particles, with their surface iron being removed, did not generate ·OH. The iron-containing leachate from these washings was able to enhance ·OH production as untreated particles did. Therefore, the presence of adsorbed iron on the surface of the SiO$_{2}$ particles is presented as a possible mechanism of UPFs-induced ·OH generation. The SiO$_{2}$ acted as an inert substrate, and the surface of ultra-fine SiO$_{2}$ particles acted as a carrier for iron.
Starting Page	1033
Ending Page	1041
Page Count	9
File Format	PDF
ISSN	10069291
Journal	Science in China Series B: Chemistry
Volume Number	52
Issue Number	7
e-ISSN	18622771
Language	English
Publisher	SP Science in China Press
Publisher Date	2009-06-27
Publisher Place	Heidelberg
Access Restriction	Subscribed
Subject Keyword	ultra-fine particles nano-particles ·OH oxidative stress size-effect Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Chemistry

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