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| Content Provider | Springer Nature Link |
|---|---|
| Author | Silva, Rosi Zani Yunes, Rosendo Augusto Souza, Márcia Maria Monache, Franco Delle Cechinel Filho, Valdir |
| Copyright Year | 2010 |
| Abstract | The antinociceptive properties of some fractions and two pure compounds, conocarpan and orientin, obtained from P. solmsianum leaves were investigated in several models of pain in mice. The results indicated that this plant exhibits a promising antinociceptive profile, as it produces active principles which are several times more active than some reference drugs used for comparison. The main compound tested, orientin, caused potent and dose-dependent effects against acetic acid-induced writhing and capsaicin- and glutamate-induced nociception, being more effective against the first one, with an ID$_{50}$ value of 6.5 mg/kg (14.5 µmol/kg). Orientin was about 20-fold more potent than acetylsalicylic acid and 3.5-fold more active than indomethacin. The antinociceptive effects of this plant may be attributed, at least partially, to the presence of conocarpan and, in particular, to the flavonoid orientin. |
| Starting Page | 402 |
| Ending Page | 408 |
| Page Count | 7 |
| File Format | |
| ISSN | 13403443 |
| Journal | Journal of Natural Medicines |
| Volume Number | 64 |
| Issue Number | 4 |
| e-ISSN | 18610293 |
| Language | English |
| Publisher | Springer Japan |
| Publisher Date | 2010-05-15 |
| Publisher Place | Japan |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Piper solmsianum Antinociception Conocarpan Orientin Pharmacy Medicinal Chemistry Complementary & Alternative Medicine Plant Sciences Pharmacology/Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science |
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