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| Content Provider | Springer Nature Link |
|---|---|
| Author | Pérez Barrón, Gabriela Ávila Acevedo, José Guillermo García Bores, Ana María Montes, Sergio García Jiménez, Sara León Rivera, Ismael Rubio Osornio, Moisés Monroy yola, Antonio |
| Copyright Year | 2014 |
| Abstract | Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the irreversible loss of dopaminergic neurons in the nigrostriatal pathway with subsequent dopamine deficiency. Environmental causes have been proposed through molecules, such as 1-methyl-4-phenylpyridinium (MPP$^{+}$), to induce oxidative stress. The methanolic extract of plants of the genus Buddleja has been reported to have in vitro and in vivo antioxidant properties to protect against neuronal death. In the present study, the neuroprotective effect of Buddleja cordata methanolic extract in the MPP$^{+}$ PD rat model was investigated. Animals were administered orally with 50 or 100 mg/kg of methanolic extract every 24 h for 14 days. Twenty hours later, rats were infused with an intrastriatal stereotaxic microinjection of 10 µg MPP$^{+}$ in 8 μl sterile saline solution. Six days later, the animals were treated with 1 mg/kg apomorphine to record ipsilateral rotations for 1 h. All the rats were killed by decapitation and the lesioned striatum was dissected for dopamine and lipid peroxidation quantifications. Both methanolic extract doses led to a significantly lower (P < 0.05) number of ipsilateral rotations (75–80 %). This behavioral protection was corroborated with 60 % level of dopamine preservation (P < 0.05) and 90 % decrease in the formation of lipidic fluorescent products in the striatum (P < 0.05). This study demonstrates the antioxidant and neuroprotective effect of Buddleja cordata methanolic extract in the MPP$^{+}$ PD rat model, possibly due to the involvement of phenylpropanoids. |
| Starting Page | 86 |
| Ending Page | 93 |
| Page Count | 8 |
| File Format | |
| ISSN | 13403443 |
| Journal | Journal of Natural Medicines |
| Volume Number | 69 |
| Issue Number | 1 |
| e-ISSN | 18610293 |
| Language | English |
| Publisher | Springer Japan |
| Publisher Date | 2014-09-25 |
| Publisher Place | Tokyo |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Buddleja cordata MPP$^{+}$ Parkinson’s disease Verbascoside Hydroxytyrosol Pharmacology/Toxicology Plant Sciences Complementary & Alternative Medicine Medicinal Chemistry Pharmacy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science |
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