NDLI: The dioRAMA project: assessment of dioxin-like activity in sediments and fish (Rutilus rutilus) in support of the ecotoxicological characterization of sediments

Content Provider	Springer Nature Link
Author	Eichbaum, Kathrin Brinkmann, Markus Buchinger, Sebastian Hecker, Markus Engwall, Magnus Bavel, Bert Reifferscheid, Georg Hollert, Henner
Copyright Year	2013
Abstract	Given the complex interactions of re-suspension processes and bioavailability of sediment-bound pollutants such as dioxin-like chemicals, there is need for a better integrative understanding of the cause–effect relationship of these pollutants. Currently, the majority of studies investigating potential risks of these chemicals only focus on characterizing sediment extracts via in vitro bioassays, thereby disregarding bioavailability, uptake, metabolism, and elimination rates of these compounds in vivo. To determine to which extent mechanism-specific effects in vitro reflect possible adverse effects in vivo, the research project dioRAMA, involving partnership between the Institute for Environmental Research of RWTH Aachen University and the Department Biochemistry/Ecotoxicology of the German Federal Institute of Hydrology, was established.Animals from an elevated trophic level—common roach (Rutilus rutilus)—will be exposed to sediments from two major German rivers. Exposure will be performed in a system that enables a concurrent monitoring of environmental parameters. In parallel, in vitro studies will be conducted to determine dioxin-like potentials of sediment and fish extracts from the in vivo exposure experiments using different cell lines with varying endpoints. Moreover, extract fractionation procedures, using the strategy of effect-directed analysis, will enable the detection of specific contaminant groups responsible for the biological activity observed.A closer interconnection between applied ecotoxicological science and regulatory needs will facilitate the improved assessment of dioxin-like compounds in sediment and biota. Consequently, this will enable their application in sediment management programs, which is one of the main goals of the dioRAMA project.
Starting Page	770
Ending Page	774
Page Count	5
File Format	PDF
ISSN	14390108
Journal	Journal of Soils and Sediments
Volume Number	13
Issue Number	4
e-ISSN	16147480
Language	English
Publisher	Springer-Verlag
Publisher Date	2013-02-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biomarker of effect and exposure Dioxin-like activity Rutilus rutilus Soil Science & Conservation Environment Environmental Physics
Content Type	Text
Resource Type	Article
Subject	Stratigraphy Earth-Surface Processes

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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