NDLI: Assessment of DNA damage in Brazilian workers occupationally exposed to pesticides: a study from Central Brazil

Content Provider	Springer Nature Link
Author	Khayat, Carolinne Borges Costa, Emília Oliveira Alves Gonçalves, Macks Wendhell Cruz e Cunha, Damiana Mirian Cruz, Alex Silva Araújo Melo, Caroline Oliveira Bastos, Rogério Pereira Cruz, Aparecido Divi Melo e Silva, Daniela
Copyright Year	2013
Abstract	We evaluated 41 rural workers occupationally exposed to pesticides and 32 subjects as a control group, using the micronucleus (MN) and the comet assay. For the comet assay, we evaluated the peripheral blood, and for the MN, we sampled cells from the oral epithelium. Damage to DNA was measured by tail length, % DNA in tail (% tail), olive tail moment (OTM), and tail moment (TM). The exposed group presented an 8× increase in MN frequency, when compared to the control group (p <0.05). When we contrasted the MN frequencies between the individuals that use and do not use personal protective equipment, we found a mean of 7.5 MN (57 % variance) and 12.1 MN (130 % variance), respectively. The binucleated cells were 0.04 and 0.005, in the exposed and control groups, respectively, indicating 8× increase in the number of binucleated cells, when comparing the groups (p <0.05). In the comet assay, we demonstrated statistically significant differences in three parameters (% DNA, OTM, and TM) indicating that the rural workers presented high levels of genomic damages. Our results indicate that occupational exposure to pesticides could cause genome damage in somatic cells, representing a potential health risk to Brazilian rural workers that deal constantly with agrochemicals without adequate personal protection equipment.
Starting Page	7334
Ending Page	7340
Page Count	7
File Format	PDF
ISSN	09441344
Journal	Environmental Science and Pollution Research
Volume Number	20
Issue Number	10
e-ISSN	16147499
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-05-03
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Occupational exposure Pesticides DNA damage MN Comet assay Rural workers Environment Environmental Chemistry Ecotoxicology Environmental Health Atmospheric Protection/Air Quality Control/Air Pollution Waste Water Technology Water Pollution Control Water Management Aquatic Pollution
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Evaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approach

Assessment of DNA damage in floriculturists in southern Brazil

Assessment of genotoxic effects of lead in occupationally exposed workers

Oxidative stress and early DNA damage in workers exposed to iron-rich metal fumes

Assessment of DNA damage in Brazilian workers occupationally exposed to pesticides: a study from Central Brazil.

The potential DNA toxic changes among workers exposed to antimony trioxide

Biomonitoring of agricultural workers exposed to pesticide mixtures in Guerrero state, Mexico, with comet assay and micronucleus test

Do GSTT1 and GSTM1 polymorphisms influence intoxication events in individuals occupationally exposed to pesticides?

Micronucleus Assay as a Biomarker of Genotoxicity in the Occupational Exposure to Agrochemicals in Rural Workers

Assessment of DNA damage in Brazilian workers occupationally exposed to pesticides: a study from Central Brazil

Similar Documents

Evaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approach

Assessment of DNA damage in floriculturists in southern Brazil

Assessment of genotoxic effects of lead in occupationally exposed workers

Oxidative stress and early DNA damage in workers exposed to iron-rich metal fumes

Assessment of DNA damage in Brazilian workers occupationally exposed to pesticides: a study from Central Brazil.

The potential DNA toxic changes among workers exposed to antimony trioxide

Biomonitoring of agricultural workers exposed to pesticide mixtures in Guerrero state, Mexico, with comet assay and micronucleus test

Do GSTT1 and GSTM1 polymorphisms influence intoxication events in individuals occupationally exposed to pesticides?

Micronucleus Assay as a Biomarker of Genotoxicity in the Occupational Exposure to Agrochemicals in Rural Workers

Assessment of DNA damage in Brazilian workers occupationally exposed to pesticides: a study from Central Brazil