NDLI: The impact of aluminum, fluoride, and aluminum–fluoride complexes in drinking water on chronic kidney disease

Content Provider	Springer Nature Link
Author	Wasana, Hewa M. S. Perera, Gamage D. R. K. Gunawardena, Panduka S. Bandara, Jayasundera
Copyright Year	2015
Abstract	It is suspected that drinking water containing fluoride and aluminum results in negative health effects especially on brain, liver, and kidney. In this investigation, the effect of F, Al, and AlF$_{x}$ complex on chronic kidney disease (CKD) was investigated. Mice were treated either with WHO recommended or slightly higher F and Al levels in drinking water. Treatment solutions contained 0.05–10.0 mg/L of F, 0.08–10.0 mg/L of Al, or 0.07–15 mg/L of AlF$_{x}$, and the treatment period was 42 weeks. Blood urea level and creatinine levels were investigated as a measure of malfunction of kidneys. Histopathological evaluations of kidney tissues were carried out to assess the extent of damage that F, Al, and AlF$_{x}$ complex could cause. It was demonstrated that the treated drinking water containing F and Al with par with WHO or moderately above the WHO levels or AlF$_{x}$ in low level (0.07–15 mg/L) does not lead to CKD in mice.
Starting Page	11001
Ending Page	11009
Page Count	9
File Format	PDF
ISSN	09441344
Journal	Environmental Science and Pollution Research
Volume Number	22
Issue Number	14
e-ISSN	16147499
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-03-20
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aluminum Fluoride toxicity Chronic kidney disease Water quality Environment and public health Environment Environmental Chemistry Ecotoxicology Environmental Health Atmospheric Protection/Air Quality Control/Air Pollution Waste Water Technology Water Pollution Control Water Management Aquatic Pollution
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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