NDLI: Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles

Content Provider	Springer Nature Link
Author	Sugimoto, Masahiro Saruta, Juri Matsuki, Chisa To, Masahiro Onuma, Hiromi Kaneko, Miku Soga, Tomoyoshi Tomita, Masaru Tsukiki, Keiichi
Copyright Year	2012
Abstract	Mass spectrometry (MS)-based metabolomic methods enable simultaneous profiling of hundreds of salivary metabolites, and may be useful to diagnose a wide range of diseases using saliva. However, few studies have evaluated the effects of physiological or environmental factors on salivary metabolomic profiles. Therefore, we used capillary electrophoresis-MS to analyze saliva metabolite profiles in 155 subjects with reasonable oral hygiene, and examined the effects of physiological and environmental factors on the metabolite profiles. Overall, 257 metabolites were identified and quantified. The global profiles and individual metabolites were evaluated by principle component analysis and univariate tests, respectively. Collection method, collection time, sex, body mass index, and smoking affected the global metabolite profiles. However, age also might contribute to the bias in sex and collection time. The profiles were relatively unaffected by other parameters, such as alcohol consumption and smoking, tooth brushing, or the use of medications or nutritional supplements. Temporomandibular joint disorders had relatively greater effects on salivary metabolites than other dental abnormalities (e.g., stomatitis, tooth alignment, and dental caries). These findings provide further insight into the diversity and stability of salivary metabolomic profiles, as well as the generalizability of disease-specific biomarkers.
Starting Page	454
Ending Page	463
Page Count	10
File Format	PDF
ISSN	15733882
Journal	Metabolomics
Volume Number	9
Issue Number	2
e-ISSN	15733890
Language	English
Publisher	Springer US
Publisher Date	2012-09-29
Publisher Institution	Metabolomics Society
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Capillary electrophoresis Metabolomics Mass spectrometry Oral hygiene Saliva Temporomandibular joint disorders Biochemistry Molecular Medicine Cell Biology Developmental Biology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry

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