NDLI: Metabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride

Content Provider	Springer Nature Link
Author	Wang, Xiaoyan Lin, Jingchao Chen, Tianlu Zhou, Mingmei Su, Mingming Jia, Wei
Copyright Year	2010
Abstract	Diammonium glycyrrhizinate (DG), a constitutent of Glycyrrhiza uralensis, has a protective effect on hepatic injury, hepatisis and cirrhosis. To date, the mechanism has been poorly understood, especially at the metabolic level. A metabolomic profiling study was performed to characterize the carbon tetrachloride (CCl$_{4}$) induced global metabolic alteration and the protective effects of DG in Sprague-Dawley rats. Urinary and hepatic tissue metabolic profiling revealed that CCl$_{4}$ perturbed the amino acid metabolism (alanine, glycine, leucine), tricarboxylic acid cycle (citrate), lipid metabolism (unsaturated fatty acids) and gut microbiota related metabolites. Our results also indicated that DG was able to attenuate CCl$_{4}$ perturbed metabolic pathways and ameliorated biochemical markers of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Total cholesterol (TCHO). This global metabolomic approach also revealed full metabolic recovery takes longer than apparent and conventional histological and biochemical markers.
Starting Page	226
Ending Page	236
Page Count	11
File Format	PDF
ISSN	15733882
Journal	Metabolomics
Volume Number	7
Issue Number	2
e-ISSN	15733890
Language	English
Publisher	Springer US
Publisher Date	2010-09-23
Publisher Institution	Metabolomics Society
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Metabolomics Acute liver injure Diammonium glycyrrhizinate Carbon tetrachloride Molecular Medicine Developmental Biology Cell Biology Biomedicine general Biochemistry
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry

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