NDLI: N-cadherin expression is regulated by UTP in schwannoma cells

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Purinergic Signalling : Volume 9, Issue 1, March 2013

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N-cadherin expression is regulated by UTP in schwannoma cells

Content Provider	Springer Nature Link
Author	Martiáñez, Tania Lamarca, Aloa Casals, Nuria Gella, Alejandro
Copyright Year	2012
Abstract	Schwann cells (SCs) are peripheral myelinating glial cells that express the neuronal Ca$^{2+}$-dependent cell adhesion molecule, neural cadherin (N-cadherin). N-cadherin is involved in glia–glia and axon–glia interactions and participates in many key events, which range from the control of axonal growth and guidance to synapse formation and plasticity. Extracellular UTP activates P2Y purinergic receptors and exerts short- and long-term effects on several tissues to promote wound healing. Nevertheless, the contribution of P2Y receptors in peripheral nervous system functions is not completely understood. The current study demonstrated that UTP induced a dose- and time-dependent increase in N-cadherin expression in SCs. Furthermore, N-cadherin expression was blocked by the P2 purinoceptor antagonist suramin. The increased N-cadherin expression induced by UTP was mediated by phosphorylation of mitogen-activated protein kinases (MAPKs), such as Jun N-terminal kinase, extracellular-regulated kinase and p38 kinase. Moreover, the Rho kinase inhibitor Y27632, the phospholipase C inhibitor U73122 and the protein kinase C inhibitor calphostin C attenuated the UTP-induced activation of MAPKs significantly. Extracellular UTP also modulated increased in the expression of the early transcription factors c-Fos and c-Jun. We also demonstrated that the region of the N-cadherin promoter between nucleotide positions −3698 and −2620, which contained one activator protein-1-binding site, was necessary for UTP-induced gene expression. These results suggest a novel role for P2Y purinergic receptors in the regulation of N-cadherin expression in SCs.
Starting Page	259
Ending Page	270
Page Count	12
File Format	PDF
ISSN	15739538
Journal	Purinergic Signalling
Volume Number	9
Issue Number	2
e-ISSN	15739546
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-12-28
Publisher Institution	International Purine Club
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	N-cadherin Schwann cells UTP P2Y receptors Mitogen-activated protein kinases Peripheral nervous system Biomedicine general Pharmacology/Toxicology Human Physiology Neurosciences Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Cellular and Molecular Neuroscience

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N-cadherin expression is regulated by UTP in schwannoma cells

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N-cadherin expression is regulated by UTP in schwannoma cells

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