NDLI: ADPβS evokes microglia activation in the rabbit retina in vivo

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Contents of Volume 1 (2005)

Author index to Volume 1 (2005)

Purinergic Signalling : Volume 1, Issue 3, September 2005

Purinergic Signalling : Volume 1, Issue 2, June 2005

Purinergic Signalling : Volume 1, Issue 1, December 2004

ADPβS evokes microglia activation in the rabbit retina in vivo

Content Provider	Springer Nature Link
Author	Uckermann, Ortrud Uhlmann, Susann Wurm, Antje Reichenbach, Andreas Wiedemann, Peter Bringmann, Andreas
Copyright Year	2005
Abstract	To investigate whether stimulation of purinergic P2Y$_{1}$ receptors modulates the activation of microglial and Müller glial cells in the rabbit retina in vivo, adenosine 5-O-(2-thiodiphosphate) (ADPβS; 2 mM in 100 μl saline), a non-hydrolyzable ADP analogue, was intravitreadly applied into control eyes or onto retinas that were experimentally detached from the pigment epithelium. Both retinal detachment and application of ADPßS onto control retinas induced phenotype alterations of the microglial cells (decrease of soma size, retraction of cell processes) and had no influence on microglial cell density. ADPßS application onto detached retinas accelerated the process retraction and resulted in a strongly decreased density of microglial cells. The effects of ADPßS on microglia density and phenotype in detached retinas were partially reversed by co-application of the selective inhibitor of P2Y$_{1}$ receptors, MRS-2317 (3 mM in 100 μl saline). ADPßS apparently did not influence Müller cell gliosis, as determined by electrophysiological and calcium imaging records. It is concluded that rabbit retinal microglial cells express functional P2Y$_{1}$ receptors in vivo, and that activation of these receptors stimulates phenotype alterations that are characteristical for microglia activation.
Starting Page	383
Ending Page	387
Page Count	5
File Format	PDF
ISSN	15739538
Journal	Purinergic Signalling
Volume Number	1
Issue Number	4
e-ISSN	15739546
Language	English
Publisher	Springer Netherlands
Publisher Date	2005-12-03
Publisher Institution	International Purine Club
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	adenosine 5-triphosphate gliosis microglia Müller glial cell P2 receptor retina retinal detachment Biomedicine general Pharmacology/Toxicology Human Physiology Neurosciences Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Cellular and Molecular Neuroscience

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