NDLI: Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

Please wait, while we are loading the content...

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

Content Provider	Springer Nature Link
Author	Künzli, Beat M. Bernlochner, Maria Isabell Rath, Stephan Käser, Samuel Csizmadia, Eva Enjyoji, Keiichi Cowan, Peter d’Apice, Anthony Dwyer, Karen Rosenberg, Robert Perren, Aurel Friess, Helmut Maurer, Christoph A. Robson, Simon C.
Copyright Year	2011
Abstract	Despite improvements in prevention and management of colorectal cancer (CRC), uncontrolled tumor growth with metastatic spread to distant organs remains an important clinical concern. Genetic deletion of CD39, the dominant vascular and immune cell ectonucleotidase, has been shown to delay tumor growth and blunt angiogenesis in mouse models of melanoma, lung and colonic malignancy. Here, we tested the influence of CD39 on CRC tumor progression and metastasis by investigating orthotopic transplanted and metastatic cancer models in wild-type BALB/c, human CD39 transgenic and CD39 deficient mice. We also investigated CD39 and P2 receptor expression patterns in human CRC biopsies. Murine CD39 was expressed by endothelium, stromal and mononuclear cells infiltrating the experimental MC-26 tumors. In the primary CRC model, volumes of tumors in the subserosa of the colon and/or rectum did not differ amongst the treatment groups at day 10, albeit these tumors rarely metastasized to the liver. In the dissemination model, MC-26 cell line-derived hepatic metastases grew significantly faster in CD39 over-expressing transgenics, when compared to CD39 deficient mice. Murine P2Y2 was significantly elevated at both mRNA and protein levels, within the larger liver metastases obtained from CD39 transgenic mice where changes in P2X7 levels were also noted. In clinical samples, lower levels of CD39 mRNA in malignant CRC tissues appeared associated with longer duration of survival and could be linked to less invasive tumors. The modulatory effects of CD39 on tumor dissemination and differential levels of CD39, P2Y2 and P2X7 expression in tumors suggest involvement of purinergic signalling in these processes. Our studies also suggest potential roles for purinergic-based therapies in clinical CRC.
Starting Page	231
Ending Page	241
Page Count	11
File Format	PDF
ISSN	15739538
Journal	Purinergic Signalling
Volume Number	7
Issue Number	2
e-ISSN	15739546
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-04-02
Publisher Institution	International Purine Club
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CD39 NTPDase1 P2 receptors Colorectal cancer MC-26 cancer cell line Pharmacology/Toxicology Biomedicine general Cancer Research Neurosciences Human Physiology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Purinergic signalling and cancer

NTPDase1 activity attenuates microglial phagocytosis

P2 receptors in cardiovascular regulation and disease ( Purinergic Signalling , Volume 4 , Issue 1 )

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

Role of nitric oxide on purinergic signalling in the cochlea

Pathophysiology of astroglial purinergic signalling

P2 receptors in atherosclerosis and postangioplasty restenosis ( Purinergic Signalling , Volume 3 , Issue 1-2 )

P2 receptors in atherosclerosis and postangioplasty restenosis ( Purinergic Signalling , Volume 2 , Issue 3 )

P2 receptors in macrophage fusion and osteoclast formation

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

Similar Documents

Purinergic signalling and cancer

NTPDase1 activity attenuates microglial phagocytosis

P2 receptors in cardiovascular regulation and disease ( Purinergic Signalling , Volume 4 , Issue 1 )

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

Role of nitric oxide on purinergic signalling in the cochlea

Pathophysiology of astroglial purinergic signalling

P2 receptors in atherosclerosis and postangioplasty restenosis ( Purinergic Signalling , Volume 3 , Issue 1-2 )

P2 receptors in atherosclerosis and postangioplasty restenosis ( Purinergic Signalling , Volume 2 , Issue 3 )

P2 receptors in macrophage fusion and osteoclast formation

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer