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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lai, Henry Cari, Monserrat Singh, Narendra |
| Copyright Year | 1997 |
| Abstract | Previous research in our laboratory has shown that various effects of radiofrequency electromagnetic radiation (RFR) exposure on the nervous system are mediated by endogenous opioids in the brain. We have also found that acute exposure to RFR induced DNA strand breaks in brain cells of the rat. The present experiment was carried out to investigate whether endogenous opioids are also involved in RFR‐induced DNA strand breaks. Rats were treated with the opioid antagonist naltrexone (1 mg/kg, IP) immediately before and after exposure to 2450 MHz pulsed (2 µs pulses, 500 pps) RFR at a power density of 2 mW/cm$^{2}$ (average whole body specific absorption rate of 1.2 W/kg) for 2 hours. DNA double strand breaks were assayed in brain cells at 4 hours after exposure using a microgel electrophoresis assay. Results showed that the RFR exposure significantly increased DNA double strand breaks in brain cells of the rat, and the effect was partially blocked by treatment with naltrexone. Thus, these data indicate that endogenous opioids play a mediating role in RFR‐induced DNA strand breaks in brain cells of the rat. |
| Starting Page | 471 |
| Ending Page | 476 |
| Page Count | 6 |
| File Format | |
| ISSN | 10220038 |
| Journal | Wireless Networks |
| Volume Number | 3 |
| Issue Number | 6 |
| e-ISSN | 15728196 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 1997-01-01 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Computer Communication Networks Electronic and Computer Engineering Business Information Systems |
| Content Type | Text |
| Resource Type | Article |
| Subject | Computer Networks and Communications Information Systems Electrical and Electronic Engineering |
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