NDLI: Aureobasidium pullulans as a source of liamocins (heavy oils) with anticancer activity

Content Provider	Springer Nature Link
Author	Manitchotpisit, Pennapa Watanapoksin, Ramida Price, Neil P. J. Bischoff, Kenneth M. Tayeh, Malatee Teeraworawit, Sudarat Kriwong, Saranya Leathers, Timothy D.
Copyright Year	2014
Abstract	Liamocins are structurally unique, heavier-than-water “oils” produced by certain strains of Aureobasidium pullulans. The aim of the current study is to identify new sources of liamocins and evaluate their potential as anticancer agents. Nine strains of A. pullulans from phylogenetic clades 8, 9, and 11 were examined for the first time for production of liamocins. Strains in these clades have only been isolated from tropical environments, and all strains tested here were from various locations in Thailand. Strains RSU 9, RSU 21, and RSU 29, all from clade 11, produced from 7.0 to 8.6 g liamocins/l from medium containing 5 % sucrose. These are the highest yields of liamocins that we have found thus far. These strains also produced from 9.4 to 17 g pullulan/l. The structural identity of liamocins was confirmed by matrix-assisted laser desorption/ionization mass spectrometry; differential spectra were obtained in which the dominant ion was either at about m/z 805.5 or m/z 949.6, consistent with the structure of liamocins. Liamocins from A. pullulans strains RSU 9 and RSU 21 inhibited two human breast cancer cell lines and a human cervical cancer cell line (IC$_{50}$ values of 32.2 ± 1.4 to 63.1 ± 2.4 μg liamocins/ml) but were not toxic to a normal cell line. Liamocins weakly inhibited a strain of Enterococcus faecalis, but did not inhibit strains of Lactobacillus fermentum, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Thus, A. pullulans phylogenetic clade 11 is a promising source of liamocins, and these compounds merit further examination as potential anticancer agents.
Starting Page	2199
Ending Page	2204
Page Count	6
File Format	PDF
ISSN	09593993
Journal	World Journal of Microbiology and Biotechnology
Volume Number	30
Issue Number	8
e-ISSN	15730972
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-03-22
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Anticancer agents Aureobasidium pullulans Liamocins Phylogeny Pullulan Applied Microbiology Biotechnology Biochemistry Environmental Engineering/Biotechnology Microbiology
Content Type	Text
Resource Type	Article
Subject	Physiology Medicine Applied Microbiology and Biotechnology Biotechnology

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Erratum to: Aureobasidium pullulans as a source of liamocins (heavy oils) with anticancer activity

Production of anti-streptococcal liamocins from agricultural biomass by Aureobasidium pullulans

Thailand habitats as sources of pullulan-producing strains of Aureobasidium pullulans

Effect of two-stage temperature on pullulan production by Aureobasidium pullulans

Heavy oils produced by Aureobasidium pullulans

The effect of Tween 80 on the polymalic acid and pullulan production by Aureobasidium pullulans CCTCC M2012223

Phylogenetic classification of Aureobasidium pullulans strains for production of feruloyl esterase

Characterization of UGPase from Aureobasidium pullulans NRRL Y-12974 and Application in Enhanced Pullulan Production

Production of pure β-glucan by Aureobasidium pullulans after pullulan synthetase gene disruption

Aureobasidium pullulans as a source of liamocins (heavy oils) with anticancer activity

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Erratum to: Aureobasidium pullulans as a source of liamocins (heavy oils) with anticancer activity

Production of anti-streptococcal liamocins from agricultural biomass by Aureobasidium pullulans

Thailand habitats as sources of pullulan-producing strains of Aureobasidium pullulans

Effect of two-stage temperature on pullulan production by Aureobasidium pullulans

Heavy oils produced by Aureobasidium pullulans

The effect of Tween 80 on the polymalic acid and pullulan production by Aureobasidium pullulans CCTCC M2012223

Phylogenetic classification of Aureobasidium pullulans strains for production of feruloyl esterase

Characterization of UGPase from Aureobasidium pullulans NRRL Y-12974 and Application in Enhanced Pullulan Production

Production of pure β-glucan by Aureobasidium pullulans after pullulan synthetase gene disruption

Aureobasidium pullulans as a source of liamocins (heavy oils) with anticancer activity