NDLI: Computer Simulations to Identify in Polyproteins of FMDV OK1 and A12 Strains Putative Nonapeptides with Amino Acid Motifs for Binding to BoLA Class I A11 and A20 Haplotype Molecules

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Computer Simulations to Identify in Polyproteins of FMDV OK1 and A12 Strains Putative Nonapeptides with Amino Acid Motifs for Binding to BoLA Class I A11 and A20 Haplotype Molecules

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Virus Genes : Volume 14, Issue 1, January 1997

Computer Simulations to Identify in Polyproteins of FMDV OK1 and A12 Strains Putative Nonapeptides with Amino Acid Motifs for Binding to BoLA Class I A11 and A20 Haplotype Molecules

Content Provider	Springer Nature Link
Author	Becker, Yechiel
Copyright Year	1997
Abstract	The computer program “Findpatterns” was used to search FMDV- (OK1 and A12 strains) coded structural and nonstructural proteins for the availability of putative proteasome-generated nonapeptides with motifs reported for BoLA class I A11 and A20 haplotypes. These BoLA class I A11 and A20 nonapeptide motifs are identical to motifs of nonapeptides that interact with the peptide binding grooves of HLA class I B35 and B27 haplotypes, respectively. The computer findpattern program was used to analyze the FMDV-coded polyproteins for proteolytically cleavable nonapeptides with motifs for binding to the peptide binding grooves of BoLA class I A11 or 20 haplotypes. The computer simulations revealed that FMDV-infected cells (keratinocytes and antigen presenting cells. e.g., dendritic Langerhans cells in bovines) may be able to present viral nonapeptides to CD8$^{+}$ cytolytic T cells (CTLs) in a BoLA-restricted manner. The role of the cellular arm of the immune response i n the protection of bovines against FMDV is not known. Thus, the present computer analysis may encourage further experiments to develop a new generation of FMDV nonapeptide vaccines to stimulate the anti-FMDV cytolytic T cell response in bovine so this would complement the humoral immune response achieved by immunization with the inactivated virus vaccine.
Starting Page	123
Ending Page	129
Page Count	7
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	14
Issue Number	2
e-ISSN	1572994X
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1997-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Medical Microbiology Virology Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

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