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| Content Provider | Springer Nature Link |
|---|---|
| Author | Díaz Quiñonez, José Alberto Ortíz Alcántara, Joanna Vázquez Pichardo, Mauricio Luz Torres Rodríguez, María Nuñez León, Alma Torres Longoria, Belem López Martínez, Irma Ruiz Matus, Cuitláhuac Kuri Morales, Pablo Ramírez González, José Ernesto |
| Copyright Year | 2016 |
| Abstract | We identified 25 autochthonous chikungunya virus cases in Mexico, initially detected by RT-PCR targeting the E1 gene and propagated in C6/36 Aedes albopictus cells, in 2014. To determine the type of virus found, in a previous report, the genomes of 2 CHIKV strains were fully sequenced. Genome sequence analysis revealed that these isolates from Mexico belonged to the Asian genotype, and a phylogenetic association with the circulating strain in the British Virgin Islands was also established in the same year. This was further supported by changes in specific amino acids, E2-V368A and 6K-L20M. For these reasons, it can be inferred that the route of virus entry to Mexico was held across the countries in the Caribbean and Central America. The presence of E1-A226V mutation associated with more efficient replication in the salivary gland of the A. albopictus mosquito was not observed. Interestingly, a newly acquired NSP4-S399C mutation was observed; however, the significance of changes in amino acid found in non-structural proteins in autochthonous strains remains to be elucidated. |
| Starting Page | 127 |
| Ending Page | 129 |
| Page Count | 3 |
| File Format | |
| ISSN | 09208569 |
| Journal | Virus Genes |
| Volume Number | 52 |
| Issue Number | 1 |
| e-ISSN | 1572994X |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2016-01-19 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Chikungunya virus Methagenomics Phylogeny Mexico Medical Microbiology Virology Plant Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Genetics Medicine Molecular Biology |
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