NDLI: Duck tembusu virus and its envelope protein induce programmed cell death

Content Provider	Springer Nature Link
Author	Shaozhou, Wulin Li, Chenxi Zhang, Qingshan Meng, Runzhe Gao, Youlan Liu, Hongyu Bai, Xiaofei Chen, Yuhuan Liu, Ming Liu, Siguo Zhang, Yun
Copyright Year	2015
Abstract	The cytopathic effect produced in cells infected with duck tembusu virus (DTMUV) suggests that this emerging virus may induce apoptosis in primary cultures of duck embryo fibroblasts (DEF). Here, we present evidence that DTMUV infection of cultured cells activates apoptosis and that the ability of DTMUV to induce apoptosis is not restricted to cell type because DTMUV-induced apoptosis in duck and mammalian host cells. We further investigated which viral components induce apoptosis in DTMUV-infected host cells. The major envelope glycoprotein (E) was investigated for its apoptotic activities in expressed cells. Transient expression of the E protein alone triggered apoptosis in DEF, Vero, and BHK cells. Expression of the E protein resulted in activation of caspase-3-like proteases in cultured cells. These results indicate that infection of cells with DTMUV or expression of DTMUV E protein alone induces apoptosis, providing the basis for future to define the molecules that play key roles in the fate of DTMUV-infected cells.
Starting Page	39
Ending Page	44
Page Count	6
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	51
Issue Number	1
e-ISSN	1572994X
Language	English
Publisher	Springer US
Publisher Date	2015-06-09
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Flaviviruses Duck tembusu virus Envelope glycoprotein E Apoptosis DEVDase activity Medical Microbiology Virology Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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