NDLI: Genetic analysis of nonstructural genes (NS1 and NS2) of H9N2 and H5N1 viruses recently isolated in Israel

Content Provider	Springer Nature Link
Author	Banet ach, Caroline Panshin, Alexander Golender, Natalia Simav, Lubov Rozenblut, Ezra Pokamunski, Shimon Pirak, Michael Tendler, Yevgenii García, Maricarmen Gelman, Boris Pasternak, Ruslan Perk, Shimon
Copyright Year	2006
Abstract	The avian influenza virus subtype H9N2 affects wild birds, domestic poultry, swine, and humans; it has circulated amongst domestic poultry in Israel during the last 6 years. The H5N1 virus was recorded in Israel for the first time in March 2006. Nonstructural (NS) genes and NS proteins are important in the life cycle of the avian influenza viruses. In the present study, NS genes of 21 examples of H9N2 and of two examples of H5N1 avian influenza viruses, isolated in Israel during 2000–2006, were completely sequenced and phylogenetically analyzed. All the H9N2 isolates fell into a single group that, in turn, was subdivided into three subgroups in accordance with the time of isolation; their NS1 and NS2 proteins possessed 230 and 121 amino acids, respectively. The NS1 protein of the H5N1 isolates had five amino acid deletions, which was typical of highly pathogenic H5N1 viruses isolated in various countries during 2005–2006. Comparative analysis showed that the NS proteins of the H9N2 Israeli isolates contained few amino acid sequences associated with high pathogenicity or human host specificity.
Starting Page	157
Ending Page	168
Page Count	12
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	34
Issue Number	2
e-ISSN	1572994X
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-12-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Avian influenza virus Genetic analysis H9N2 H5N1 NS genes Plant Sciences Virology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

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