NDLI: Oncogenic Marek’s disease viruses lacking the 132 base pair repeats can still be attenuated by serial in vitro cell culture passages

Please wait, while we are loading the content...

Molecular characterization of two Pepino mosaic virus variants from imported tomato seed reveals high levels of sequence identity between Chilean and US isolates

Multiple alternative splicing to exons II and III of viral interleukin-8 (vIL-8) in the Marek’s disease virus genome: the importance of vIL-8 exon I

Genetic properties of medium (M) and small (S) genomic RNA segments of Seoul hantavirus isolated from Rattus norvegicus and antigenicity analysis of recombinant nucleocapsid protein

Genetic variability of bovine viral diarrhoea virus subtypes at 3′-nontranslated region

Outbreaks of avian influenza H6N2 viruses in chickens arose by a reassortment of H6N8 and H9N2 ostrich viruses

Sequence variations of Epstein–Barr virus LMP1 gene in nasal NK/T-cell lymphoma

Difference of Epstein–Barr virus isolates from Japanese patients and African Burkitt’s lymphoma cell lines based on the sequence of latent membrane protein 1

Mutational analysis of the GDD sequence motif of classical swine fever virus RNA-dependent RNA polymerases

Changes in VP3 and VP5 genes during the attenuation of the very virulent infectious bursal disease virus strain Gx isolated in China

Identification, phenotypic analysis, and full-length nucleotide sequence of a Dutch Coxsackievirus A20 isolate

Oncogenic Marek’s disease viruses lacking the 132 base pair repeats can still be attenuated by serial in vitro cell culture passages

Virus Genes : Volume 33

Virus Genes : Volume 32

Virus Genes : Volume 31

Virus Genes : Volume 30

Virus Genes : Volume 29

Virus Genes : Volume 28

Virus Genes : Volume 27

Virus Genes : Volume 26

Virus Genes : Volume 25

Virus Genes : Volume 24

Virus Genes : Volume 23

Virus Genes : Volume 22

Virus Genes : Volume 21

Virus Genes : Volume 20

Virus Genes : Volume 19

Virus Genes : Volume 18

Virus Genes : Volume 17

Virus Genes : Volume 16

Virus Genes : Volume 15

Virus Genes : Volume 14

Oncogenic Marek’s disease viruses lacking the 132 base pair repeats can still be attenuated by serial in vitro cell culture passages

Content Provider	Springer Nature Link
Author	Silva, R. F. Gime, Isabel
Copyright Year	2006
Abstract	Marek’s disease virus (MDV) can be attenuated by serially passing the virus in cell culture. During cell culture passage, two copies of a 132 bp repeat are expanded to over 30 copies. We deleted the two copies of the 132 bp repeat region in a pathogenic MDV and demonstrated that the virus was still pathogenic. The pattern and frequency of tumors in the parental and mutant virus were the same. Early virus replication, and the appearance of persistent neurological disease were also similar between the parental and deleted virus. Nevertheless, wild-type MDV and the deletion virus could be attenuated by serial in vitro cell culture passages. Based upon analyzing the passage 40 viruses, attenuation of the MDV lacking the 132 bp repeats appears to occur in a manner that is analogous to the process occurring wild-type MDV attenuation. Whatever process is involved in the cell culture attenuation of MDV, the mechanism does not involve the 132 bp repeat region.
Starting Page	87
Ending Page	90
Page Count	4
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	34
Issue Number	1
e-ISSN	1572994X
Language	English
Publisher	Springer US
Publisher Date	2006-08-22
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Herpesvirus Lymphoma Cosmid Deletion mutant Chicken Plant Sciences Virology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Stability of Marek’s disease virus 132-bp repeats during serial in vitro passages

Dynamic equilibrium of Marek’s disease genomes during in vitro serial passage

Polymorphisms in the repeat long regions of oncogenic and attenuated pathotypes of Marek’s disease virus 1

Deletion of the Marek’s disease virus UL41 gene (vhs) has no measurable effect on latency or pathogenesis

Clustering of mutations within the inverted repeat regions of a serially passaged attenuated gallid herpesvirus type 2 strain

Marek’s disease viruses lacking either R-LORF10 or LORF4 have altered virulence in chickens

Comparative sequence analysis of a highly oncogenic but horizontal spread-defective clone of Marek’s disease virus

Co-infection of Marek's disease virus with different oncogenic immunosuppressive viruses in chicken flocks.

Chicken embryo fibroblasts with oncogenic marek’s (2000).

Oncogenic Marek’s disease viruses lacking the 132 base pair repeats can still be attenuated by serial in vitro cell culture passages

Similar Documents

Stability of Marek’s disease virus 132-bp repeats during serial in vitro passages

Dynamic equilibrium of Marek’s disease genomes during in vitro serial passage

Polymorphisms in the repeat long regions of oncogenic and attenuated pathotypes of Marek’s disease virus 1

Deletion of the Marek’s disease virus UL41 gene (vhs) has no measurable effect on latency or pathogenesis

Clustering of mutations within the inverted repeat regions of a serially passaged attenuated gallid herpesvirus type 2 strain

Marek’s disease viruses lacking either R-LORF10 or LORF4 have altered virulence in chickens

Comparative sequence analysis of a highly oncogenic but horizontal spread-defective clone of Marek’s disease virus

Co-infection of Marek's disease virus with different oncogenic immunosuppressive viruses in chicken flocks.

Chicken embryo fibroblasts with oncogenic marek’s (2000).

Oncogenic Marek’s disease viruses lacking the 132 base pair repeats can still be attenuated by serial in vitro cell culture passages