NDLI: A Shope Fibroma virus PYRIN-only protein modulates the host immune response

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A Shope Fibroma virus PYRIN-only protein modulates the host immune response

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A Shope Fibroma virus PYRIN-only protein modulates the host immune response

Content Provider	Springer Nature Link
Author	Dorfleutner, Andrea Talbott, Siera J. Bryan, Nicole B. Funya, Kristin N. Rellick, Stephanie L. Reed, John C. Shi, Xianglin Rojanasakul, Yon Flynn, Daniel C. Stehlik, Christian
Copyright Year	2007
Abstract	PYRIN domain (PYD) proteins have recently emerged as important signaling molecules involved in the development of innate immunity to intracellular pathogens through activation of inflammatory mediator pathways. ASC is the central adaptor protein, which links pathogen recognition by PYD-containing pathogen recognition receptors to the activation of downstream effectors, including activation of Caspase-1 and NF-κB. The cellular PYD-only protein 1 (cPOP1) can block the recruitment of ASC to activated PAN receptors and thereby functions as an endogenous inhibitor of the PYD-mediated signal transduction pathway. Here we describe the identification and characterization of a Shope Fibroma homolog to cPOP1. Like cPOP1, a Shope Fibroma virus-encoded POP (vPOP), co-localizes and directly associates with ASC and inhibits PYD-mediated signal transduction. Poxviruses are known to encode immune evasive proteins to promote host cell infection and suppression of the host immune response. Poxvirus-encoded vPOPs represent a novel class of immune evasive proteins and impair the host response by blocking Cryopyrin and ASC inflammasome-mediated activation of pro-Caspase-1 and subsequent processing of pro-interleukin (IL)-1β, and expression of vPOPs causes activation of NF-κB.
Starting Page	685
Ending Page	694
Page Count	10
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	35
Issue Number	3
e-ISSN	1572994X
Language	English
Publisher	Springer US
Publisher Date	2007-08-04
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Caspase-1 IL-1β Inflammasome NF-κB PYRIN domain Poxvirus Plant Sciences Virology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

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