NDLI: Comparing the ability of a series of viral protein-expressing plasmid DNAs to protect against H5N1 influenza virus

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Comparing the ability of a series of viral protein-expressing plasmid DNAs to protect against H5N1 influenza virus

Content Provider	Springer Nature Link
Author	Chen, Quanjiao Kuang, Haimen Wang, Huadong Fang, Fang Yang, Zhongdong Zhang, Zhiping Zhang, Xianen Chen, Ze
Copyright Year	2008
Abstract	Avian influenza has been regarded as a human health threat. A major measure to prevent its outbreak is vaccination. In this study, a series of expression plasmids carrying the hemagglutinin (HA), neuraminidase (NA), nucleoprotein (NP), matrix protein 1 (M1), and matrix protein 2 (M2) genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were constructed. These plasmids were administered to mice by electroporation (50 μg for each per administration, 1–5 times, at an interval of 2 weeks), and the mice were challenged with the homologous virus later. The mice immunized with HA plasmid once and the NA plasmid twice survived 100%, and those with NP plasmid showed 60–80% survival rate with at least three immunizations. The mice immunized with M1 plasmid survived 25% with five immunizations, while M2 plasmid had no protection even with five immunizations. The mixture of M1 and NP plasmids protected 95% of the mice against the homologous virus, and 80% of the mice against a challenge with heterologous H1N1 (PR8) virus. Moreover, the homologous protection lasted at least 6 months. Our data provided a basis for selecting multiple-component AIV vaccines.
Starting Page	30
Ending Page	38
Page Count	9
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	38
Issue Number	1
e-ISSN	1572994X
Language	English
Publisher	Springer US
Publisher Date	2008-12-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	H5N1 Hemagglutinin Neuraminidase Matrix protein Nucleoprotein DNA vaccine Plant Sciences Virology Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

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