NDLI: The Main Regulatory Region in the Murine PSP Gene is a Parotid Gland Enhancer

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The Main Regulatory Region in the Murine PSP Gene is a Parotid Gland Enhancer

Content Provider	Springer Nature Link
Author	Laursen, Jesper Krogh pedersen, Helene Dagnaes hansen, Frederik Hjorth, J. Peter
Copyright Year	1998
Abstract	The murine PSP gene is expressed at a high-level in the parotid glands. To extend the knowledge of parotid gland expression and develop tools for expression of heterologous proteins in this tissue, the regulation of the PSP gene was studied using transgenic mice. High-level parotid gland expression of the PSP gene was indicated to depend on a novel regulatory region situated between −8.0 and −6.5 kb. Together with previous results this indicates that the main regulatory elements in the PSP gene are situated between −8.0 to −3.1 kb. This region was shown to activate a heterologous SV40 early promoter in the parotid glands of transgenic mice, suggesting that the PSP gene is controlled by enhancer sequences. A novel Psp derived 9.7 kb parotid gland expression cassette, Lama IV, carrying all known regulatory regions in the PSP gene was expressed at high-levels in the parotid glands and should prove highly useful for expression of heterologous proteins in the saliva of transgenic mice.
Starting Page	413
Ending Page	420
Page Count	8
File Format	PDF
ISSN	09628819
Journal	Transgenic Research
Volume Number	7
Issue Number	6
e-ISSN	15739368
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Plant Sciences Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science

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