NDLI: The Effect of DNA Repair Defects on Reproductive Performance in Nucleotide Excision Repair (NER) Mouse Models: An Epidemiological Approach

Content Provider	Springer Nature Link
Author	Tsai, P.S. Nielen, M. Horst, G.T.J. Colenbrander, B. Heesterbeek, J.A.P. Vlissingen, J.M. Fentener
Copyright Year	2005
Abstract	In this study, we used an epidemiological approach to analyze an animal database of DNA repair deficient mice on reproductive performance in five Nucleotide Excision Repair (NER) mutant mouse models on a C57BL/6 genetic background, namely CSA, CSB, XPA, XPC [models for the human DNA repair disorders Cockayne Syndrome (CS) and xeroderma pigmentosum (XP), respectively] and mHR23B (not associated with human disease). This approach allowed us to detect and quantify reproductive effects based on a relatively small number of matings. We measured and quantified the scale of the effect between factors that might influence reproductive performance (i.e. age at co-housing, seasons) and reproductive parameters (i.e. litter size and pairing-to-birth interval –‘pbi’). Besides, we detected and quantified the differences in reproductive performance between wild type mice and heterozygous/homozygous NER mutant mice. From our analyses, we found impaired reproduction in heterozygous and homozygous knock out mice; in particular, reduced litter size and lengthened pbi was related to the NER mutation-mHR23B, in heterozygous couples, even if they were otherwise phenotypically normal. Heterozygous mHR23B couples produced a 6.6-fold lower number of mHR23B$^{−/−}$ pups than indicated by Mendelian expectation; other genetic deficiencies studied were not statistically significant from each other or wild type controls. We concluded that careful epidemiological evaluations by analysis of animal database could provide reliable information on reproductive performance and detect deviations that would remain unnoticed without this. Also, some managerial aspects of mouse breeding could be evaluated.
Starting Page	845
Ending Page	857
Page Count	13
File Format	PDF
ISSN	09628819
Journal	Transgenic Research
Volume Number	14
Issue Number	6
e-ISSN	15739368
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	animal management system epidemiology mutant mice nucleotide excision repair reproduction Human Genetics Plant Sciences Plant Genetics & Genomics Animal Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A novel transcript for DNA repair gene Ercc1 in mouse skin

Mutant mouse models of oxidative stress

Skeletal defects in Osterix-Cre transgenic mice

Erratum to: ParA resolvase catalyzes site-specific excision of DNA from the Arabidopsis genome

Evaluation of CRE-mediated excision approaches in Arabidopsis thaliana

Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach

Mechanism of random integration of foreign DNA in transgenic mice

Functional verification of a porcine myostatin propeptide mutant

ParA resolvase catalyzes site-specific excision of DNA from the Arabidopsis genome

The Effect of DNA Repair Defects on Reproductive Performance in Nucleotide Excision Repair (NER) Mouse Models: An Epidemiological Approach

Similar Documents

A novel transcript for DNA repair gene Ercc1 in mouse skin

Mutant mouse models of oxidative stress

Skeletal defects in Osterix-Cre transgenic mice

Erratum to: ParA resolvase catalyzes site-specific excision of DNA from the Arabidopsis genome

Evaluation of CRE-mediated excision approaches in Arabidopsis thaliana

Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach

Mechanism of random integration of foreign DNA in transgenic mice

Functional verification of a porcine myostatin propeptide mutant

ParA resolvase catalyzes site-specific excision of DNA from the Arabidopsis genome

The Effect of DNA Repair Defects on Reproductive Performance in Nucleotide Excision Repair (NER) Mouse Models: An Epidemiological Approach