NDLI: Expression of the Newcastle disease virus fusion protein in transgenic maize and immunological studies

Content Provider	Springer Nature Link
Author	Guerrero Andrade, Octavio Loza Rubio, Elizabeth Olivera Flores, Teresa Fehérvári Bone, Tamás Gómez Lim, Miguel Angel
Copyright Year	2006
Abstract	Transgenic plants have been employed successfully as a low-cost system for the production of therapeutically valuable proteins, including antibodies, antigens and hormones. Here, we report the expression of the fusion (F) gene of the Newcastle disease virus (NDV) in transgenic maize plants. The expression of the transgene, driven by the maize ubiquitin promoter, caused accumulation of the F protein in maize kernels. The presence of the transgene was verified by Southern and western blots. Feeding chickens with kernels containing the F protein induced the production of antibodies, which conferred protection against a viral challenge. This protection was comparable to that conferred by a commercial vaccine. Possible uses of this plant-based F protein as a potential mucosal vaccine are discussed.
Starting Page	455
Ending Page	463
Page Count	9
File Format	PDF
ISSN	09628819
Journal	Transgenic Research
Volume Number	15
Issue Number	4
e-ISSN	15739368
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2006-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Transgenic plants Recombinant proteins Maize Newcastle disease virus Chickens Human Genetics Molecular Medicine Plant Sciences Plant Genetics & Genomics Animal Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science

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