NDLI: Gene expression profiling of HGF/Met activation in neonatal mouse heart

Content Provider	Springer Nature Link
Author	Gatti, Stefa Leo, Christian Gallo, Simona Sala, Valentina Bucci, Enrico Natale, Massimo Cantarella, Daniela Medico, Enzo Crepaldi, Tiziana
Copyright Year	2012
Abstract	Hepatocyte Growth Factor (HGF) controls growth and differentiation in different cell types, including cardiac cells. However, its downstream effectors are poorly understood. To investigate the transcriptional targets of HGF, we analyzed the hearts of neonatal mice with cardiomyocyte-specific HGF overexpression with whole genome DNA microarrays. When comparing HGF expressing versus control hearts, we found a total of 249 transcripts with significant gene expression changes (210 upregulated and 39 downregulated). Gene Ontology (GO) annotation analysis revealed that the transcripts modulated by HGF were enriched for metabolic functions including: protein translation, vesicle-mediated transport, regulation of transcription, regulation of muscle development. Using an automated literature meta-analysis approach, we obtained a co-occurrence network oriented to the positive regulatory role of Myc and Notch1 in controlling some of the genes which are downstream to HGF. GO analysis of this network returned genes involved in the regulation of heart development. HGF positively controls MyocD, an activator of cardiac gene expression, and Hdac5, an inhibitor of cardiac growth. These results may unveil a new role of HGF in the modulation of signaling pathways implicated in the activation or repression of cardiomyogenesis.
Starting Page	579
Ending Page	593
Page Count	15
File Format	PDF
ISSN	09628819
Journal	Transgenic Research
Volume Number	22
Issue Number	3
e-ISSN	15739368
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-12-06
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hepatocyte Growth Factor Met receptor Heart development Cardiac muscle Microarrays System biology Molecular Medicine Plant Genetics & Genomics Animal Genetics and Genomics Plant Sciences Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A mouse model for spatial and temporal expression of HGF in the heart

Arabidopsis thaliana Full Genome Longmer Microarrays: A Powerful Gene Discovery Tool for Agriculture and Forestry

Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish

Erratum to: Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

In situ analysis of Raidd-beta-galactosidase fusion gene expression in transgenic mouse midgestation embryos

Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts

Gene expression profiling of HGF/Met activation in neonatal mouse heart

Similar Documents

A mouse model for spatial and temporal expression of HGF in the heart

Arabidopsis thaliana Full Genome Longmer Microarrays: A Powerful Gene Discovery Tool for Agriculture and Forestry

Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish

Erratum to: Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice

In situ analysis of Raidd-beta-galactosidase fusion gene expression in transgenic mouse midgestation embryos

Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts

Gene expression profiling of HGF/Met activation in neonatal mouse heart