NDLI: Functional and safety evaluation of transgenic pork rich in omega-3 fatty acids

Content Provider	Springer Nature Link
Author	Tang, Maoxue Qian, Lili Jiang, Shengwang Zhang, Jian Song, Pengkun Chen, Yaoxing Cui, Wentao Li, Kui
Copyright Year	2014
Abstract	Genetically modified animals rich in omega-3 unsaturated fatty acid offer a new strategy to improve the human health, but at the same time present a challenge in terms of food safety assessment. In this study, we evaluated the function and safety of sFat-1 transgenic pork rich in omega-3 fatty acids in mice by feeding basic diet and diets that contain wild type pork and sFat-1 transgenic pork. Blood biochemistry, haematology, peripheral T cell distributions, bacterial counts, gross necropsy, histopathology and organ weights were performed in mice fed with different doses of wild type and transgenic pork. Results indicated that both low and high dose of wild type and transgenic pork had no significant effect on blood biochemistry, T cell distribution, immunoglobulins and bacterial counts in intestine and feces. However, it was noted that both low and high dose of transgenic pork improved the liver immune system in mice, which is probably due to the beneficial contribution of high level of the “good” fatty acids in transgenic pork. There is no significant effect of transgenic pork on all other organs in mice. In summary, our study clearly demonstrated that feeding transgenic pork rich in omega-3 fatty acids did not cause any harm to mice, and in fact, improved the liver immune system.
Starting Page	557
Ending Page	571
Page Count	15
File Format	PDF
ISSN	09628819
Journal	Transgenic Research
Volume Number	23
Issue Number	4
e-ISSN	15739368
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-04-04
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	GM foods Omega-3 fatty acids Toxicity Function and safety assessment Molecular Medicine Plant Genetics & Genomics Animal Genetics and Genomics Plant Sciences Transgenics
Content Type	Text
Resource Type	Article
Subject	Genetics Animal Science and Zoology Biotechnology Agronomy and Crop Science

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