NDLI: Synthesis, characterization, and cytotoxicity of Pt(IV) complexes containing 1,10-phenanthroline and 2,2′-bipyridine and diaminocyclohexane ligands

Content Provider	Springer Nature Link
Author	Zhao, Xiaowei Zhang, Yamei Hou, Xiaonan Shi, Jianhong Shen, Shigang Huo, Shuying
Copyright Year	2017
Abstract	Four platinum(IV) complexes containing intercalating ligands [1,10-phenanthroline (phen) and 2,2′-bipyridine (bpy)] and ancillary ligands [(1S,2S)-diaminocyclohexane (SS-DACH) and (1R,2R)-diaminocyclohexane (RR-DACH)] were synthesized and characterized by $^{1}$H nuclear magnetic resonance, electrospray ionization mass spectrometry, X-ray crystal structure analysis, elemental analysis, ultraviolet absorption spectroscopy, circular dichroism spectroscopy, and electrochemical analysis. The reactions between [Pt(phen)(SS-DACH)Cl$_{2}$]$^{2+}$ and glutathione and Ac-CPFC-NH$_{2}$ were investigated by high-performance liquid chromatography. [Pt(phen)(SS-DACH)Cl$_{2}$]$^{2+}$ was reduced to its corresponding Pt(II) complex [Pt(phen)(SS-DACH)]$^{2+}$, while glutathione and Ac-CPFC-NH$_{2}$ were oxidized to glutathione-disulfide and a peptide containing an intramolecular disulfide bond, respectively. The cytotoxicities of the Pt(IV) complexes against a human non-small cell lung cancer cell line (A549) and the corresponding cisplatin-resistant cell line (A549cisR) were evaluated. These Pt(IV) complexes showed a higher activity toward A549 and A549cisR than did cisplatin. Also, the cytotoxicities of the Pt(IV) complexes were higher for A549cisR than for A549 cells. Moreover, the cytotoxicities of the (SS-DACH)-liganded platinum complexes were higher than those of the (RR-DACH)-liganded platinum complexes in either A549 or A549cisR cells. Phen-liganded platinum complexes were more cytotoxic than the bpy-liganded platinum complexes. The cytotoxicities of these Pt(IV) complexes had no correlation with reduction potentials.
Starting Page	219
Ending Page	228
Page Count	10
File Format	PDF
ISSN	03404285
Journal	Transition Metal Chemistry
Volume Number	42
Issue Number	3
e-ISSN	1572901X
Language	English
Publisher	Springer International Publishing
Publisher Date	2017-02-22
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Catalysis Physical Chemistry Inorganic Chemistry Organometallic Chemistry
Content Type	Text
Resource Type	Article
Subject	Materials Chemistry Metals and Alloys Inorganic Chemistry

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