NDLI: Spectroscopic and Analytic Properties of New Copper(II) Complex of Antiviral Drug Valacyclovir

Content Provider	Springer Nature Link
Author	Gölcü, Aybegül Dolaz, Mustafa Demirelli, Havva Diðrak, Metin Serin, Selahattin
Copyright Year	2006
Abstract	The complexation processes between Cu$^{II}$ and the antiviral drug, valacyclovir hydrochloride (H$_{2}$L), were studied under different reaction conditions, using UV-Vis, IR and mass spectra, magnetochemical, thermogravimetric, atomic absorption, conductivity, and elemental analysis data. Using the Job method, the compositions of these complexes were determined. Under the ligand (H$_{2}$L) excess (M:L = 1:1–1:10). In aqueous solutions, a binuclear violet complex Cu$_{2}$(HL)$_{2}$L(H$_{2}$O)$_{4}$ is formed, with an octahedral structure. Under comparable amounts of the reagents, in MeOH solutions, a green mononuclear complex Cu(H$_{2}$L)Cl$_{2}$ is formed. Protonation constants of the H$_{2}$L, and stability constants of its Cu$^{2+}$ complexes, were determined by potentiometric titration in H$_{2}$O media at 25 ± 0.02 °C under a N$_{2}$ atmosphere and ionic strength of 0.1 m NaCl. It has been observed that H$_{2}$L has three protonation constants. The divalent metal ion Cu$^{2+}$ forms stable 2:1 and 2:2 complexes with H$_{2}$L. The antimicrobial activity studies of the valacyclovir and it’s complexes have been studied against some gram positive species: (Corynebacterium xerosis, Bacillus brevis, Bacillus megaterium, Bacillus cereus, Mycobacterium smegmatis, Staphylococcus aureus, Micrococcus luteus, Enterococcus faecalis) and gram negative (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Yersinia enterocolitica, Kluyveromyces fragilis, Saccharomyces cerevisiae, Candida albicans) bacteriaz.
Starting Page	658
Ending Page	665
Page Count	8
File Format	PDF
ISSN	03404285
Journal	Transition Metal Chemistry
Volume Number	31
Issue Number	5
e-ISSN	1572901X
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2006-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Inorganic Chemistry Physical Chemistry Catalysis
Content Type	Text
Resource Type	Article
Subject	Materials Chemistry Metals and Alloys Inorganic Chemistry

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