NDLI: Chemical morphology: The chemistry of our shape, in vivo and in vitro

Content Provider	Springer Nature Link
Author	Scott, J. E.
Copyright Year	2007
Abstract	Our shape is defined and maintained by the connective tissues (skin, tendons, cartilages, blood vessels, etc.) or more precisely by their extracellular matrices. These highly ordered supramolecular organisations are modules of protein fibrils held together by elastic carbohydrate strings. I called these the ‘shape modules.’ The ‘laws.’ which underpin this tissue jigsaw, the changes which come with age and the insight that the concepts give in economically important disorders such as osteoarthrosis begin to provide a new and coherent picture stretching across the animal world and its evolution. This structure/function picture is built on biochemical analyses, which developed into histochemical microscopy and thence into electron histochemistry, and from nuclear magnetic resonance (NMR), molecular modelling and computer simulations on the physicochemical and biomechanical side. As usual, originality bred dissent.
Starting Page	257
Ending Page	265
Page Count	9
File Format	PDF
ISSN	10400400
Journal	Structural Chemistry
Volume Number	18
Issue Number	3
e-ISSN	15729001
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2007-03-08
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aggrecan Cartilage Chondroitan sulphate Collagen Cupromeronic blue Decoran Dermochondan sulphate Osteoarthrosis Shape module Theoretical and Computational Chemistry Physical Chemistry Computer Applications in Chemistry
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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