NDLI: Updating the Model Definition of the Gene in the Modern Genomic Era with Implications for Instruction

Content Provider	Springer Nature Link
Author	Smith, Mike U. Adkison, Linda R.
Copyright Year	2008
Abstract	Gericke and Hagberg (G & H, Sci Educ 16:849–881, 2007) recently published in this journal a thoughtful analysis of the historical progression of our understanding of the nature of the gene for use in instruction. This analysis, however, did not include the findings of the Human Genome Project (HGP), which must be included in any introductory genetics in the modern genomic era today. Many of these findings, especially the limited number of genes and the similarity of this number to that of primitive animals such as roundworms, were surprising and led to questions about the definition of the gene, many of which are addressed in this manuscript. The G & H models are also amended to include crucial concepts, including the history of determining that DNA and not protein is the molecule of inheritance, the work of Barbara McClintock and the discovery of transposons, polygenic/multi-factorial inheritance, and reverse transcription. The following discussion further extends the G & H work to include the more recent work of the ENCyclopedia Of DNA Elements (ENCODE) Project. The results of this work have resulted in even more fundamental questions about the gene. For example, large sections of the genome that were previously identified as non-protein-coding ‘junk’ have been shown to be transcribed into RNA that is likely involved in regulation of genome function that might be more crucial than the coding DNA itself in distinguishing simpler from more complex species. Should these transcribed but not translated sequences be recognized as genes? This level of questioning of our basic definition has not occurred since the modern synthesis of genetics based on the work of Watson and Crick and makes this one of the most exciting times for genetics and medicine.
Starting Page	1
Ending Page	20
Page Count	20
File Format	PDF
ISSN	09267220
Journal	Science & Education
Volume Number	19
Issue Number	1
e-ISSN	15731901
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-07-03
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Interdisciplinary Studies History Philosophy of Science Science Education
Content Type	Text
Resource Type	Article
Subject	Education

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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