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| Content Provider | Springer Nature Link |
|---|---|
| Author | Khmel, I. A. |
| Copyright Year | 2005 |
| Abstract | Global changes in cell physiology and metabolism take place in bacterial cells entering the stationary phase. The processes that ensure cell survival under adverse environmental conditions are activated, and cells with an improved resistance to many stress factors are formed as a result of the general stress response. The review considers the molecular mechanisms of cell differentiation in Gram-negative bacteria (exemplified by Escherichia coli) upon deceleration or complete suppression of cell growth, including changes in all steps of gene expression. The transition to the stationary phase is accompanied by DNA compaction, which is due to qualitative and quantitative changes in the protein composition of the nucleoid. Changes in the translation machinery under these conditions include the formation of functionally inactive 100S ribosome dimers with participation of the RMF protein. Dramatic changes are observed in the transcription machinery: while the general level of gene expression decreases, activation or induction is characteristic of many genes and operons that are silent in actively growing cells. The key role in stationary phase-associated regulation of gene transcription is played by the σ$^{S}$ subunit of RNA polymerase. Expression of the rpoS gene, which codes for σ$^{S}$, is regulated by an intricate multicomponent regulatory network, which functions at the levels of transcription of the rpoS gene, translation of the σ$^{S}$ mRNA, and proteolysis of σ$^{S}$. In addition, some issues of selection of σ$^{S}$ for transcription initiation and the roles of other factors in regulating gene expression in cells with decelerated or completely suppressed growth are discussed. Data are presented on the role of quorum-sensing systems in regulating the processes that occur at a high density of a bacterial population. |
| Starting Page | 968 |
| Ending Page | 984 |
| Page Count | 17 |
| File Format | |
| ISSN | 10227954 |
| Journal | Russian Journal of Genetics |
| Volume Number | 41 |
| Issue Number | 9 |
| e-ISSN | 16083369 |
| Language | English |
| Publisher | Nauka/Interperiodica |
| Publisher Date | 2005-01-01 |
| Publisher Place | Moscow |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Microbial Genetics and Genomics Animal Genetics and Genomics Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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