NDLI: M31R and R335C polymorphic variants of the IL8RA gene in Russian and Buryat patients with atopic bronchial asthma

Content Provider	Springer Nature Link
Author	Voronko, O. E. Dmitrieva Zdorova, E. V. Gabaeva, M. V. Latysheva, E. A. Storozhakov, G. I. Lemza, S. V. Hobrakova, V. B. Grigorieva, E. V. Bodoev, N. V.
Copyright Year	2011
Abstract	To test the M31R and R335C polymorphisms of the Il8RA gene for association with atopic bronchial asthma (BA), the allele and genotype frequency distributions of the polymorphisms were studied in Russian patients from Moscow and Buryat patients from Ulan-Ude. The study involved two Russian groups, one including 291 DNA samples of patients with atopic BA, and the other, 266 DNA samples of healthy people. The two Buryat groups included 124 and 152 DNA samples from patients with atopic BA and healthy people, respectively. The M31R polymorphism proved to be associated with atopic BA in Russians. Allele Arg and genotype Met/Arg suggested a higher risk of BA (OR = 4.45, P = 0.003 and OR = 4.58, P = 0.003, respectively), while allele Met and genotype Met/Met were associated with a lower risk (OR = 0.22, P = 0.003 and OR = 0.22, P = 0.003, respectively). The R335C polymorphism was not associated with atopic BA in Russians and was in Buryats. Allele Arg and homozygous genotype Arg/Arg suggested a higher risk of the disease (OR = 3.06, P = 0.030 and OR = 3.20, P = 0.027, respectively), while allele Cys and genotype Arg/Cys suggested a lower risk (OR = 0.33, P = 0.030 and OR = 0.31, P = 0.027, respectively). The results support the role of the IL8RA gene in atopic BA.
Starting Page	1111
Ending Page	1116
Page Count	6
File Format	PDF
ISSN	10227954
Journal	Russian Journal of Genetics
Volume Number	47
Issue Number	9
e-ISSN	16083369
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2011-09-16
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Animal Genetics and Genomics Human Genetics Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics

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