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| Content Provider | Springer Nature Link |
|---|---|
| Author | Bocharova, A. V. Stepav, V. A. Marusin, A. V. Kharkov, V. N. Vagaitseva, K. V. Fedorenko, O. Yu. Bokhan, N. A. Semke, A. V. Ivava, S. A. |
| Copyright Year | 2017 |
| Abstract | A replicative analysis of associations of 15 SNPs located in the regions of 11 genes (TCF4, VRK2, NOTCH4, ZNF804A, AGBL1, RELN, ZFP64P1, KCNB2, CSMD1, CPVL, NRIP1) and three intergenic regions (SLCO6A1/LINCOO491, LOC105376248/LOC105376249, SPA17/NRGN) with schizophrenia was conducted in the Russian population of the Siberian region. These SNPs were previously identified in genome-wide association studies (GWAS) of schizophrenia and cognitive abnormalities. The present study confirmed associations of KCNB2 rs2247572, CSMD1 rs2616984, and intergenic rs12807809 located in SPA17/NRGN with schizophrenia. It was established that the frequency of the CSMD1 rs2616984 G/G genotype was higher in patients compared to the control group (OR = 1.73; CI: 1.14–2.62; р = 0.0337). The frequencies of the KCNB2 rs2247572 TT genotype (OR = 0.41; CI: 0.20–0.87; р = 0.0485) and intergenic rs12807809 CT genotype located in SPA17/NRGN (OR = 0.70; CI: 0.53–0.94; р = 0.0464) were significantly decreased in patients compared to the control group. |
| Starting Page | 139 |
| Ending Page | 146 |
| Page Count | 8 |
| File Format | |
| ISSN | 10227954 |
| Journal | Russian Journal of Genetics |
| Volume Number | 53 |
| Issue Number | 1 |
| e-ISSN | 16083369 |
| Language | English |
| Publisher | Pleiades Publishing |
| Publisher Date | 2017-02-07 |
| Publisher Place | Moscow |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | schizophrenia cognitive endophenotypes association study multifactorial diseases Russian population Human Genetics Animal Genetics and Genomics Microbial Genetics and Genomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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