NDLI: Peculiarities of phosphoglycerate kinase-1 pseudogene evolution in Schrenck salamander (Salamandrella schrenckii Strauch 1870)

Content Provider	Springer Nature Link
Author	Malyarchuk, B. A. Denisova, G. A. Derenko, M. V.
Copyright Year	2013
Abstract	Processed copies of genes generally evolve in neutral mode as pseudogenes, however, some of them might be important sources of new functional genes. The ψPGK1 pseudogene has been discovered in Schrenck salamander (Salamandrella schrenckii, Amphibia, Caudata, Hynobiidae) via polymerase chain reaction used to amplify the phosphoglycerate kinase 1 gene (PGK1). This pseudogene is an intronless copy of PGK1 gene absent of exon 6. Analysis of ψPGK1 pseudogene polymorphism has demonstrated that it lacks mutations, which results in shifts in the stop codons and reading frames, as well as that the interspecies variation of this pseudogene was inconsistent with the neutral model of evolution. In addition, the pattern of phylogeographic differentiation of the ψPGK1 variants mainly coincides with that observed in mitochondrial DNA. These observations allow it to be suggested that the ψPGK1 pseudogene is a new functional gene in the Schrenck salamander.
Starting Page	722
Ending Page	729
Page Count	8
File Format	PDF
ISSN	10227954
Journal	Russian Journal of Genetics
Volume Number	49
Issue Number	7
e-ISSN	16083369
Language	English
Publisher	Springer US
Publisher Date	2013-07-12
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Animal Genetics and Genomics Microbial Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics

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Peculiarities of phosphoglycerate kinase-1 pseudogene evolution in Schrenck salamander (Salamandrella schrenckii Strauch 1870)