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  1. Russian Journal of Developmental Biology
  2. Russian Journal of Developmental Biology : Volume 45
  3. Russian Journal of Developmental Biology : Volume 45, Issue 5, September 2014
  4. Regeneration and fibrosis of corneal tissues
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Russian Journal of Developmental Biology : Volume 48
Russian Journal of Developmental Biology : Volume 47
Russian Journal of Developmental Biology : Volume 46
Russian Journal of Developmental Biology : Volume 45
Russian Journal of Developmental Biology : Volume 45, Issue 6, November 2014
Russian Journal of Developmental Biology : Volume 45, Issue 5, September 2014
Age-related changes in the rat lacrimal gland: Impressive morphology and enigmatic nature
Assisted reproductive technologies and arterial hypertension
Regeneration and fibrosis of corneal tissues
Gene NANA regulates cell proliferation in Arabidopsis thaliana shoot apical meristem without interaction with CLV1, CLV2, CLV3
Tissue oxygen partial pressure in organs of chickens in the second half of embryogenesis and first days after hatching
Reproductive strategy of the alien Ponto-Caspian cladocerans Cercopagis pengoi (Ostroumov, 1891) in the Baltic Sea (by example of the Vistula Lagoon)
Morphological changes in ventricular germinal zone and neocortex of the cerebral hemispheres in human fetuses and newborns on weeks 22–40 of prenatal development
Study of possible involvement of MEK mitogen-activated protein kinase and TGF-β receptor in planarian regeneration processes using pharmacological inhibition analysis
Russian Journal of Developmental Biology : Volume 45, Issue 4, July 2014
Russian Journal of Developmental Biology : Volume 45, Issue 3, May 2014
Russian Journal of Developmental Biology : Volume 45, Issue 2, March 2014
Russian Journal of Developmental Biology : Volume 45, Issue 1, January 2014
Russian Journal of Developmental Biology : Volume 44
Russian Journal of Developmental Biology : Volume 43
Russian Journal of Developmental Biology : Volume 42
Russian Journal of Developmental Biology : Volume 41
Russian Journal of Developmental Biology : Volume 40
Russian Journal of Developmental Biology : Volume 39
Russian Journal of Developmental Biology : Volume 38
Russian Journal of Developmental Biology : Volume 37
Russian Journal of Developmental Biology : Volume 36
Russian Journal of Developmental Biology : Volume 35
Russian Journal of Developmental Biology : Volume 34
Russian Journal of Developmental Biology : Volume 33
Russian Journal of Developmental Biology : Volume 32
Russian Journal of Developmental Biology : Volume 31

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Regeneration and fibrosis of corneal tissues

Content Provider Springer Nature Link
Author Simirskii, V. N.
Copyright Year 2014
Abstract In this review, the features of the regeneration of corneal tissue and its disorders leading to the development of fibrosis are considered. The data on the presence of stem (clonogenic) cell pool in the corneal tissues (epithelium, endothelium, stroma) are given; these cells can serve as a source for regeneration of the tissues at injury or various diseases. The main steps of regeneration of corneal tissues and their disorders that lead to outstripping proliferation of myofibroblasts and secretion of extracellular matrix in the wound area and eventually cause the formation of connective tissue scar and corneal opacity are considered. Particular attention is given to the successes of translational medicine in the treatment of corneal tissue fibrosis. The methods of cell therapy aimed at the restoration of stem cell pool of corneal tissues are the most promising. Gene therapy provides more opportunities; one of its main objectives is the suppression of the myofibroblast proliferation responsible for the development of fibrosis.
Starting Page 257
Ending Page 266
Page Count 10
File Format PDF
ISSN 10623604
Journal Russian Journal of Developmental Biology
Volume Number 45
Issue Number 5
e-ISSN 16083326
Language English
Publisher Pleiades Publishing
Publisher Date 2014-09-12
Publisher Place Moscow
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword tissue regeneration fibrosis epithelial-mesenchymal transition myofibroblasts stem cell cell and gene therapy cornea Developmental Biology Animal Anatomy / Morphology / Histology
Content Type Text
Resource Type Book Review
Subject Developmental Biology
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