NDLI: Antitumor immunotherapy with the use of synthetic fragments of survivin

Content Provider	Springer Nature Link
Author	Volkova, T. D. Koroev, D. O. Titova, M. A. Oboznaya, M. B. Filatova, M. P. Pankratov, A. A. Morozova, N. B. Zolotavkina, Yu. B. Yakubovskaya, R. I. Volpina, O. M.
Copyright Year	2008
Abstract	The endogenous protein survivin is present in tumor cells and inhibits apoptosis. The influence of vaccination of mice by survivin fragments on growth of various types of tumors was studied in order to examine the possibility of creation of an antitumor vaccinating agent on its basis. Two peptides corresponding to the 118–144 and (80–88)-(153–165) sequences of survivin 2B were chosen and synthesized on the basis of literature data and theoretical calculations. Their ability to stimulate antibody production in mice of the C57BL/6J line (b-haplotype) and in BDF1 hybrids (b × d-haplotype) was investigated. Both peptides were shown to stimulate production of antibodies that bound the recombinant survivin in the BDF1 mice. Immunization of BDF1 and C57BL/6J mice with the recombinant survivin resulted in formation of antibodies that reacted with 118–144 peptide. The effect of preventive vaccination with the peptides and the recombinant protein on dynamics of growth of several species of tumors was studied. Vaccination with the (80–88)-(153–165) peptide was found to cause an antitumor effect in BDF1 mice suffered from sarcoma S-37. Thus, creation of antitumor agent on the basis of this peptide is a promising area of further studies.
Starting Page	409
Ending Page	414
Page Count	6
File Format	PDF
ISSN	10681620
Journal	Russian Journal of Bioorganic Chemistry
Volume Number	34
Issue Number	4
e-ISSN	1608330X
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2008-07-19
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	antitumor immunotherapy survivin synthetic peptides T-epitopes antibodies Biomedicine general Organic Chemistry Bioorganic Chemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry

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