NDLI: Guanidinyl benzothiazole derivatives: Synthesis and structure activity relationship studies of a novel series of potential antimicrobial and antioxidants

Content Provider	Springer Nature Link
Author	Bhat, Mahesh Belagali, S. L.
Copyright Year	2016
Abstract	A series of N-phenyl-substituted and disubstituted guanidinyl benzothiazole derivatives 4a–4m were synthesized and characterized as novel antimicrobial and antioxidant agents. The in-vitro antioxidant activities of these compounds were evaluated and compared with commercial antioxidants, using ascorbic acid (AA) and employing 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid (ABTS) assay. The results showed that IC$_{50}$ values of compounds 4a and 4m were similar to the IC$_{50}$ values of the standard. This assay indicates the good activities of these compounds. In addition, the in-vitro antimicrobial activities of these compounds were evaluated and the results demonstrated that the compounds 4i and 4l exhibited excellent antimicrobial activities. Compounds 4c and 4i having electron withdrawing groups at p-position and compound 4l and 4m having electron donating groups at o-position showed better antimicrobial activities compared to the standard.
Starting Page	6195
Ending Page	6208
Page Count	14
File Format	PDF
ISSN	09226168
Journal	Research on Chemical Intermediates
Volume Number	42
Issue Number	7
e-ISSN	15685675
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-01-29
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Guanidinyl benzothiazole Antioxidant activity DPPH assay ABTS assay Antimicrobial Catalysis Physical Chemistry Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry

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