NDLI: Radiolabeling, quality control, and biodistribution of $^{99m}$Tc-sulfadiazine as an infection imaging agent

Content Provider	Springer Nature Link
Author	Essouissi, I. Darghoutha, F. Saied, N. M. Saidi, Maroua Kaun, A. Saidi, Mouldi
Copyright Year	2015
Abstract	—Sulfadiazine (antibiotic used for treating bacterial infections) was labeled with $^{99m}$Tc with the aim of the development of a new radiopharmaceutical for infection imaging. The influence of the reaction parameters such as the substrate and SnCl$_{2}$·2H$_{2}$O concentrations, pH of the reaction mixture, and reaction time on the labeling yield was examined, and the labeling conditions were optimized. The maximum radiochemical yield of $^{99m}$Tc-sulfadiazine (94.7%) was obtained by using 50 µg of SnCl$_{2}$·2H$_{2}$O and 1 mg of sulfadiazine at pH 5. The radiochemical purity of the labeled compound was evaluated by ITLC and HPLC. The biological distribution of $^{99m}$Tc-sulfadiazine in mice with experimentally induced Staphylococcus aureus infection in the right thigh was studied, and the bacterial infected thigh/normal thigh (target-to-nontarget, T/NT) ratio was evaluated. The T/NT ratio for $^{99m}$Tc-sulfadiazine was found to be 3.6, which is comparable to the commercially available $^{99m}$Tc-ciprofloxacin (3.8), indicating that $^{99m}$Tc-sulfadiazine can be used for infection imaging.
Starting Page	307
Ending Page	311
Page Count	5
File Format	PDF
ISSN	10663622
Journal	Radiochemistry
Volume Number	57
Issue Number	3
e-ISSN	16083288
Language	English
Publisher	Pleiades Publishing
Publisher Date	2015-06-06
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	sulfadiazine technetium-99m radiolabeling infection diagnosis Nuclear Chemistry Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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