NDLI: Inhibitory Effect of Grapefruit Juice on the Genotoxic Damage Induced by Ifosfamide in Mouse

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Inhibitory Effect of Grapefruit Juice on the Genotoxic Damage Induced by Ifosfamide in Mouse

Content Provider	Springer Nature Link
Author	Álvarez González, Isela Madrigal Bujaidar, Eduardo Sánchez García, Vanesa Y.
Copyright Year	2010
Abstract	The consumption of grapefruit juice (GJ) has been associated with various activities potentially beneficial for human health, including protection against the DNA damage produced by various compounds. In the present report, we evaluated the capability of this juice to inhibit the rate of micronucleated polychromatic erythrocytes (MNPE) and sister chromatid exchanges (SCE) induced by the antineoplastic alkylating agent ifosfamide (IF). We tested the effect of administering 100, 500, and 1000 mg/kg of GJ in mouse and obtained the following results: a) with the high dose, a reduction of 72% in the rate of SCE induced by IF; b) a mean reduction of 65.3% in the rate of MNPE compared with the damage induced by IF at 48 h post-administration; c) no modification induced by GJ either on the cellular proliferation kinetics or in the mitotic index; and d) neither induction of bone marrow cytotoxicity by GJ nor a protective effect of the juice against the cytotoxicity induced by IF. These data showed a significant inhibitory effect of GJ against the chromosome damage induced by the tested agent; they also suggest the relevance of carrying out studies to clarify the involved mechanism of action as well as to determine the cancer chemopreventive capacity of the juice.
Starting Page	369
Ending Page	373
Page Count	5
File Format	PDF
ISSN	09219668
Journal	Plant Foods for Human Nutrition
Volume Number	65
Issue Number	4
e-ISSN	15739104
Language	English
Publisher	Springer US
Publisher Date	2010-09-28
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antimutagenesis Grapefruit juice Ifosfamide Micronuclei Sister chromatid exchanges Mouse Plant Physiology Ecology Food Science Nutrition Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Chemistry Food Science

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