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| Content Provider | Springer Nature Link |
|---|---|
| Author | Encalada, Manuel Alejandro Hoyos, Kelly Melissa Rehecho, Sheyla Berasategi, Izaskun Ciria, Mikel García Íñiguez Ansorena, Diana Astiasarán, Iciar Navarro Blasco, Íñigo Cavero, Rita Yolanda Calvo, María Isabel |
| Copyright Year | 2011 |
| Abstract | Melissa officinalis L. (Lamiaceae) is consumed as a traditional herbal tea in the Mediterranean region. The cytotoxic effect of the 50% ethanolic and aqueous extract, determined by the MTT and NR assays, was evaluated in vitro on Human Colon Cancer Cell Line (HCT-116), using Triton 10% as positive control. The 50% ethanolic extract showed significant differences after 72 h of treatment, reducing cell proliferation to values close to 40%, even the lowest dose tested (5 μg/ml). In the MTT assay, the same extract caused the lowest cell viability with 13% at a concentration of 1,000 μg/ml after 72 h of treatment, being a value lower than Triton 10%. The antioxidant activity was also confirmed evaluating the capacity of the extracts to scavenge ABTS and DPPH radicals, and IC$_{50}$ values were highly correlated with the total phenolic and flavonoid content. Bioassay guided fractionation led to the isolation of an anti-proliferative compound, rosmarinic acid. Its structural elucidation was performed by HPLC/DAD/ESI/MS analysis. High dose of rosmarinic acid (1,000 μg/ml) was clearly cytotoxic against HCT-116 cells, with a significant decrease in cell number since the earliest time point (24 h). |
| Starting Page | 328 |
| Ending Page | 334 |
| Page Count | 7 |
| File Format | |
| ISSN | 09219668 |
| Journal | Plant Foods for Human Nutrition |
| Volume Number | 66 |
| Issue Number | 4 |
| e-ISSN | 15739104 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2011-10-01 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Lemon balm Lamiaceae Antioxidant Cytotoxicity HCT-116 RA Plant Physiology Ecology Chemistry/Food Science Nutrition Food Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Food Science |
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