NDLI: Phytoestrogens as natural prodrugs in cancer prevention: a novel concept

Content Provider	Springer Nature Link
Author	Arroo, Randolph R. J. Androutsopoulos, Vasilis Patel, Asma Surichan, Somchaiya Wilsher, Nicola Potter, Gerry A.
Copyright Year	2008
Abstract	It has been generally accepted that regular consumption of fresh fruits and vegetables is linked with a relatively low incidence of cancers (e.g. breast, cervix, and colon). A number of plant-derived compounds have been identified that are considered to play a role in cancer prevention. However, at present there is no satisfactory explanation for the cancer preventative properties of the above-mentioned compound groups. The current review is an effort to develop a consistent and unambiguous model that explains how some plant-derived compounds can prevent tumour development. The model is based on recent discoveries in the fields of genomics and drug-metabolism; notably, the discovery that CYP1 genes are highly expressed in developing tumour cells but not in the surrounding tissue, and that a variety of plant-derived compounds are substrates for the CYP1 enzymes. Our hypothesis is that some dietary compounds act as prodrugs, i.e. compounds with little or no biological effect as such, but become pharmaceutically effective when activated. More specifically, we state that the abovementioned prodrugs are only activated in CYP1-expressing cells—i.e. cells in the early stages of tumour development—to be converted into compounds which inhibit cell growth. Thus, the prodrugs selectively kill precancerous cells early in tumour development. The review focuses on the identification of naturally-occurring prodrugs that are activated by the tumour-specific CYP1 enzymes and aims to assess their role in cancer prevention.
Starting Page	431
Ending Page	443
Page Count	13
File Format	PDF
ISSN	15687767
Journal	Phytochemistry Reviews
Volume Number	7
Issue Number	3
e-ISSN	1572980X
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-03-26
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CYP1 Drug metabolism Flavones Natural products Prevention Chemistry/Food Science Organic Chemistry Biochemistry Plant Genetics & Genomics Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Plant Science Biotechnology

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