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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ferreira, Maria José U. Duarte, élia Reis, Mariana Madureira, Ana Margarida Molnár, Joseph |
| Copyright Year | 2014 |
| Abstract | Multidrug resistance (MDR) is the major obstacle for cancer chemotherapy. MDR is a multifactorial phenomenon that can result from several mechanisms, including an increased drug efflux, due to overexpression of P-glycoprotein (P-gp) that transports anticancer drugs out of the cells. Thus, the role of this transporter has made it a therapeutic target and the development of P-gp modulators considered among the most realistic approaches for overcoming P-gp-mediated MDR. Many other strategies have been proposed. One of them is the identification of compounds that selectively kill multidrug resistant cells. In our search for MDR modulators from plants, the P-gp inhibition ability of a large number of compounds on resistant cancer cells was evaluated. These compounds, presented in this review, comprise mainly diterpenes, triterpenes and phenolic derivatives. The most relevant results were obtained from two sets of compounds: macrocyclic diterpenes with the jatrophane and lathyrane scaffold, and triterpenes of the cucurbitane-type isolated from Euphorbia species and Momordica balsamina L., respectively. Additionally, some of those macrocyclic diterpenes, and ent-abietane diterpenic lactones, also isolated from Euphorbia species, were found to be selectively toxic to drug-resistant phenotypes. |
| Starting Page | 915 |
| Ending Page | 935 |
| Page Count | 21 |
| File Format | |
| ISSN | 15687767 |
| Journal | Phytochemistry Reviews |
| Volume Number | 13 |
| Issue Number | 4 |
| e-ISSN | 1572980X |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2014-03-01 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Euphorbia ent-Abietane lactones Macrocyclic diterpenes Momordica balsamina L. P-glycoprotein Triterpenes Plant Sciences Plant Genetics & Genomics Biochemistry Organic Chemistry Chemistry/Food Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Plant Science Biotechnology |
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